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Buján, J. et al.

Buján, Jurado, Gimeno, Rodriguez, Bellón,

Function of inflammatory cells and neoral cyclosporin-A in heart transplant-associated coronary vasculopathy.

The role of Sandimmun Neoral (S-n) and the immune response in transplant-associated coronary vasculopathy (TACV) was evaluated in a Lewis (Lew)-to-Fischer-344 (F344) rat abdominal heterotopic heart transplant model. Some of the transplant recipients were treated with S-n (5mg/kg/day) for 14 days post-transplant, or until sacrifice. Grafts were subjected to immunohistochemical (ED1, CD4, CD8 and alpha-actin+ cells) analysis from day 7 to 100 post-transplant. Singenic controls did not develop TACV, irrespective of whether they had received the drug or not. TACV was detected in Lew-F344 transplants regardless of S-n administration with participation of ED1+, CD8+ and alpha-actin+ cells, although its incidence was lower in animals receiving prolonged S-n treatment. In this model, accelerated arteriosclerosis of the graft appeared to be related more to the rejection effect than to the action of the immunosuppressive agent.[1]

References

Function of inflammatory cells and neoral cyclosporin-A in heart transplant-associated coronary vasculopathy. Buján, J., Jurado, F., Gimeno, M.J., Rodriguez, M., Bellón, J.M. Histol. Histopathol. (2001) [Pubmed]

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