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Chemical Compound Review

Cyclosporine A     30-ethyl-33-(1-hydroxy-2- methyl-hex-4...

Synonyms: cyclosporin A, AGN-PC-00DA8G, AG-K-75103, AG-L-65294, KBioGR_001898, ...
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Disease relevance of Ciclosporin


Psychiatry related information on Ciclosporin


High impact information on Ciclosporin


Chemical compound and disease context of Ciclosporin


Biological context of Ciclosporin


Anatomical context of Ciclosporin


Associations of Ciclosporin with other chemical compounds


Gene context of Ciclosporin

  • The London Transplant Group followed 1341 patients with cadaver renal transplants, none of whom received cyclosporine, for six months to 14 years to determine the effect on graft survival of matching donor and recipient for HLA Class I antigens (HLA-A, -B, and -C) and Class II antigens (HLA-DR, -MT, and -DQ) [30].
  • Thus, transplants matched for HLA-DR plus HLA-B and those matched for HLA-MT plus HLA-B had excellent results--even better than those reported with cyclosporine treatment [30].
  • TNF, PC, and FPS levels were normal during episodes of cyclosporine toxicity and viral infection.(ABSTRACT TRUNCATED AT 400 WORDS)[31]
  • Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine [32].
  • We demonstrate here that IL-7 in combination with phorbol 12-myristate 13-acetate can directly drive the proliferation of purified T cells and that this response is not inhibited by cyclosporine A or by antibodies to IL-2 and IL-4 [33].

Analytical, diagnostic and therapeutic context of Ciclosporin


  1. Toxicity of cyclosporine during treatment with androgens. Møller, B.B., Ekelund, B. N. Engl. J. Med. (1985) [Pubmed]
  2. Cyclosporine, sympathetic activity, and hypertension. Mark, A.L. N. Engl. J. Med. (1990) [Pubmed]
  3. Serum cyclosporine concentration and risk of acute graft-versus-host disease after allogeneic marrow transplantation. Yee, G.C., Self, S.G., McGuire, T.R., Carlin, J., Sanders, J.E., Deeg, H.J. N. Engl. J. Med. (1988) [Pubmed]
  4. Cyclosporine in severe ulcerative colitis. Vincent, F., Bensousan, T.A. N. Engl. J. Med. (1995) [Pubmed]
  5. Renal histopathologic alterations in patients treated with cyclosporine for uveitis. Palestine, A.G., Austin, H.A., Balow, J.E., Antonovych, T.T., Sabnis, S.G., Preuss, H.G., Nussenblatt, R.B. N. Engl. J. Med. (1986) [Pubmed]
  6. Methylphenidate for cyclosporine-associated organic mood disorder. Craven, J.L. The American journal of psychiatry. (1989) [Pubmed]
  7. Complex visual hallucinations and cyclosporine neurotoxicity. Steg, R.E., Garcia, E.G. Neurology (1991) [Pubmed]
  8. Cyclosporine-associated mutism in liver transplant patients. Valldeoriola, F., Graus, F., Rimola, A., Andreu, H., Santamaria, J., Catafau, A., Visa, J., Tolosa, E., Rodés, J. Neurology (1996) [Pubmed]
  9. Neurotoxicity in liver transplant recipients with cyclosporine immunosuppression. Wijdicks, E.F., Wiesner, R.H., Krom, R.A. Neurology (1995) [Pubmed]
  10. Developmental pharmacodynamics of cyclosporine. Marshall, J.D., Kearns, G.L. Clin. Pharmacol. Ther. (1999) [Pubmed]
  11. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. Childs, R., Chernoff, A., Contentin, N., Bahceci, E., Schrump, D., Leitman, S., Read, E.J., Tisdale, J., Dunbar, C., Linehan, W.M., Young, N.S., Barrett, A.J. N. Engl. J. Med. (2000) [Pubmed]
  12. Photopheresis for the prevention of rejection in cardiac transplantation. Photopheresis Transplantation Study Group. Barr, M.L., Meiser, B.M., Eisen, H.J., Roberts, R.F., Livi, U., Dall'Amico, R., Dorent, R., Rogers, J.G., Radovancević, B., Taylor, D.O., Jeevanandam, V., Marboe, C.C. N. Engl. J. Med. (1998) [Pubmed]
  13. Combination therapy with cyclosporine and methotrexate in severe rheumatoid arthritis. The Methotrexate-Cyclosporine Combination Study Group. Tugwell, P., Pincus, T., Yocum, D., Stein, M., Gluck, O., Kraag, G., McKendry, R., Tesser, J., Baker, P., Wells, G. N. Engl. J. Med. (1995) [Pubmed]
  14. Prednisone and cyclosporine in the treatment of severe Graves' ophthalmopathy. Prummel, M.F., Mourits, M.P., Berghout, A., Krenning, E.P., van der Gaag, R., Koornneef, L., Wiersinga, W.M. N. Engl. J. Med. (1989) [Pubmed]
  15. Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia. Storb, R., Deeg, H.J., Whitehead, J., Appelbaum, F., Beatty, P., Bensinger, W., Buckner, C.D., Clift, R., Doney, K., Farewell, V. N. Engl. J. Med. (1986) [Pubmed]
  16. Improvement in cyclosporine-associated gingival hyperplasia with azithromycin therapy. Wahlstrom, E., Zamora, J.U., Teichman, S. N. Engl. J. Med. (1995) [Pubmed]
  17. Marrow transplantation in patients with thalassemia responsive to iron chelation therapy. Lucarelli, G., Galimberti, M., Polchi, P., Angelucci, E., Baronciani, D., Giardini, C., Andreani, M., Agostinelli, F., Albertini, F., Clift, R.A. N. Engl. J. Med. (1993) [Pubmed]
  18. Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients. Corpier, C.L., Jones, P.H., Suki, W.N., Lederer, E.D., Quinones, M.A., Schmidt, S.W., Young, J.B. JAMA (1988) [Pubmed]
  19. Effect of dietary fish oil on renal function and rejection in cyclosporine-treated recipients of renal transplants. van der Heide, J.J., Bilo, H.J., Donker, J.M., Wilmink, J.M., Tegzess, A.M. N. Engl. J. Med. (1993) [Pubmed]
  20. Long-term efficacy and safety of cyclosporine in renal-transplant recipients. Burke, J.F., Pirsch, J.D., Ramos, E.L., Salomon, D.R., Stablein, D.M., Van Buren, D.H., West, J.C. N. Engl. J. Med. (1994) [Pubmed]
  21. Cyclosporine for plaque-type psoriasis. Results of a multidose, double-blind trial. Ellis, C.N., Fradin, M.S., Messana, J.M., Brown, M.D., Siegel, M.T., Hartley, A.H., Rocher, L.L., Wheeler, S., Hamilton, T.A., Parish, T.G. N. Engl. J. Med. (1991) [Pubmed]
  22. Factors associated with early remission of type I diabetes in children treated with cyclosporine. Bougneres, P.F., Carel, J.C., Castano, L., Boitard, C., Gardin, J.P., Landais, P., Hors, J., Mihatsch, M.J., Paillard, M., Chaussain, J.L. N. Engl. J. Med. (1988) [Pubmed]
  23. Cyclosporine-associated chronic nephropathy. Myers, B.D., Ross, J., Newton, L., Luetscher, J., Perlroth, M. N. Engl. J. Med. (1984) [Pubmed]
  24. Successful allogeneic transplantation of T-cell-depleted bone marrow from closely HLA-matched unrelated donors. Ash, R.C., Casper, J.T., Chitambar, C.R., Hansen, R., Bunin, N., Truitt, R.L., Lawton, C., Murray, K., Hunter, J., Baxter-Lowe, L.A. N. Engl. J. Med. (1990) [Pubmed]
  25. Effect of cyclosporine on total lymphocyte and T-cell counts in renal-transplant recipients. Shen, S., Weir, M., Dagher, F., Bentley, F., Revie, D., Ordonez, J., Chretien, P. N. Engl. J. Med. (1986) [Pubmed]
  26. Cyclosporine and recombinant granulocyte colony-stimulating factor in severe aplastic anemia. Kojima, S., Fukuda, M., Miyajima, Y., Matsuyama, T. N. Engl. J. Med. (1990) [Pubmed]
  27. Effect of topical cyclosporine rinse on oral lichen planus. A double-blind analysis. Eisen, D., Ellis, C.N., Duell, E.A., Griffiths, C.E., Voorhees, J.J. N. Engl. J. Med. (1990) [Pubmed]
  28. Comparison of three immunosuppressive regimens in cadaver renal transplantation: long-term cyclosporine, short-term cyclosporine followed by azathioprine and prednisolone, and azathioprine and prednisolone without cyclosporine. Hall, B.M., Tiller, D.J., Hardie, I., Mahony, J., Mathew, T., Thatcher, G., Miach, P., Thomson, N., Sheil, A.G. N. Engl. J. Med. (1988) [Pubmed]
  29. Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine. The German Aplastic Anemia Study Group. Frickhofen, N., Kaltwasser, J.P., Schrezenmeier, H., Raghavachar, A., Vogt, H.G., Herrmann, F., Freund, M., Meusers, P., Salama, A., Heimpel, H. N. Engl. J. Med. (1991) [Pubmed]
  30. Long-term follow-up in London Transplant Group recipients of cadaver renal allografts. The influence of HLA matching on transplant outcome. Festenstein, H., Doyle, P., Holmes, J. N. Engl. J. Med. (1986) [Pubmed]
  31. Tumor necrosis factor production during human renal allograft rejection is associated with depression of plasma protein C and free protein S levels and decreased intragraft thrombomodulin expression. Tsuchida, A., Salem, H., Thomson, N., Hancock, W.W. J. Exp. Med. (1992) [Pubmed]
  32. Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine. Herweijer, H., Sonneveld, P., Baas, F., Nooter, K. J. Natl. Cancer Inst. (1990) [Pubmed]
  33. Interleukin 7 is a T-cell growth factor. Chazen, G.D., Pereira, G.M., LeGros, G., Gillis, S., Shevach, E.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  34. Update for the Canadian multicentre trial of cyclosporine in renal allografts. Stiller, C.R. N. Engl. J. Med. (1984) [Pubmed]
  35. Cyclosporine in cadaveric renal transplantation. Evans, R.W. N. Engl. J. Med. (1984) [Pubmed]
  36. Carcinoma of the corneoscleral limbus in a patient treated with cyclosporine after heart transplantation. Touzeau, O., Borderie, V.M., Laroche, L. N. Engl. J. Med. (1999) [Pubmed]
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