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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Pimarane cyclooxygenase 2 ( COX-2) inhibitor and its structure-activity relationship.

The structure-activity relationship and molecular modelings of a novel pimarane COX-2 inhibitor are reported. Particularly, a series of linker extended analogues designed on the basis of these studies exhibited significantly enhanced COX-2 inhibitory activities and selectivities.[1]

References

  1. Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship. Suh, Y.G., Kim, Y.H., Park, M.H., Choi, Y.H., Lee, H.K., Moon, J.Y., Min, K.H., Shin, D.Y., Jung, J.K., Park, O.H., Jeon, R.O., Park, H.S., Kang, S.A. Bioorg. Med. Chem. Lett. (2001) [Pubmed]
 
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