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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain.

In human brain we were able to demonstrate sequence diversity of the ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/ FBPase-2). Six different isoforms of PFK-2/ FBPase-2, two of which are identical with the ubiquitous PFK-2/ FBPase-2 and the inducible PFK-2, respectively, could be identified. The heterogeneity of human brain PFK-2/FBPase-2 isoforms is generated by alternative splicing. Three hitherto unrecognized exons were detected. The multiple PFK-2/ FBPase-2 transcripts encode proteins which differ with respect to their length and to the amino acid composition of the carboxyl-termini. The isoform pattern of ubiquitous PFK-2/ FBPase-2 is more complex in human brain than in skeletal muscle and liver.[1]

References

  1. Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain. Kessler, R., Eschrich, K. Brain Res. Mol. Brain Res. (2001) [Pubmed]
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