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Gene Review

FBP2  -  fructose-1,6-bisphosphatase 2

Homo sapiens

Synonyms: D-fructose-1,6-bisphosphate 1-phosphohydrolase 2, FBPase 2, Fructose-1,6-bisphosphatase isozyme 2, Muscle FBPase
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Disease relevance of FBP2


High impact information on FBP2


Biological context of FBP2

  • The human gene (FBP2), localized at chromosome 1p36.1-2, spans about 30 kb, while the mouse gene (Fbp2) at chromosome 13B3-C1 is more compact (about 21 kb) [6].
  • A truly bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PFK2/FBP2), with two active sites synthesizes F26P(2) from fructose-6-phosphate (F6P) and ATP or degrades F26P(2) to F6P and P(i) [7].
  • Amino acid sequence comparison showed a high degree of similarity between the SaMADS D and AGL9, DEFH200, TM5, FBP2 and DEFH 72 gene products [8].
  • The effect of cyclic AMP (cAMP)-dependent phosphorylation and ADP-ribosylation on the activities of the rat liver bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2), was investigated in order to determine the role of the N-terminus in covalent modification of the enzyme [9].
  • 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis [10].

Anatomical context of FBP2

  • Taken together, these results provide evidence for a new PFK-2/FBPase-2 gene coding for a human testis isozyme [11].

Associations of FBP2 with chemical compounds

  • Furthermore, pyruvate accumulation and lactate production in RINm5F-GK-PFK-2/FBPase-2 cells were significantly lower at both 10 and 30 mmol/liter glucose than in RINm5F-GK and RINm5F cells [12].
  • 6-Phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK-2/FBPase-2) is a bifunctional enzyme responsible for the synthesis and breakdown of Fru-2,6-P2, a key metabolite in the regulation of glycolysis [11].
  • The FBPase-2 domain of the enzyme subunit bears sequence, mechanistic and structural similarity to the histidine phosphatase family of enzymes [1].

Other interactions of FBP2

  • Previous studies assigned the gene for human liver PFK-2/FBPase-2 (HGMW-approved symbol PFKFB1) to the X chromosome; however, precise localization remained ambiguous, with the gene variously placed between Xcen-q13, Xq27-q28, and Xp11.22-p11.21 [10].
  • The heterogeneity of human brain PFK-2/FBPase-2 isoforms is generated by alternative splicing [13].
  • Four of these overlapping YACs were mapped using rare-cutter restriction enzymes to provide in-depth characterization of an 820-kb region encompassing the PFK-2/ FBPase-2 and ALAS2 genes [10].


  1. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Rider, M.H., Bertrand, L., Vertommen, D., Michels, P.A., Rousseau, G.G., Hue, L. Biochem. J. (2004) [Pubmed]
  2. PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate. Okar, D.A., Manzano, A., Navarro-Sabatè, A., Riera, L., Bartrons, R., Lange, A.J. Trends Biochem. Sci. (2001) [Pubmed]
  3. Differential expression of two MADS box genes in wild-type and mutant petunia flowers. Angenent, G.C., Busscher, M., Franken, J., Mol, J.N., van Tunen, A.J. Plant Cell (1992) [Pubmed]
  4. A homolog of FBP2/KSRP binds to localized mRNAs in Xenopus oocytes. Kroll, T.T., Zhao, W.M., Jiang, C., Huber, P.W. Development (2002) [Pubmed]
  5. Glucokinase Regulatory Network in Pancreatic {beta}-Cells and Liver. Baltrusch, S., Tiedge, M. Diabetes (2006) [Pubmed]
  6. Structure and chromosomal localization of the human and mouse muscle fructose-1,6-bisphosphatase genes. Tillmann, H., Stein, S., Liehr, T., Eschrich, K. Gene (2000) [Pubmed]
  7. Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: Beyond its allosteric effects on glycolytic and gluconeogenic enzymes. Wu, C., Khan, S.A., Peng, L.J., Lange, A.J. Adv. Enzyme Regul. (2006) [Pubmed]
  8. Characterization of SaMADS D from Sinapis alba suggests a dual function of the gene: in inflorescence development and floral organogenesis. Bonhomme, F., Sommer, H., Bernier, G., Jacqmard, A. Plant Mol. Biol. (1997) [Pubmed]
  9. Role of the N-terminal region in covalent modification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: comparison of phosphorylation and ADP-ribosylation. Rosa, J.L., Pérez, J.X., Ventura, F., Tauler, A., Gil, J., Shimoyama, M., Pilkis, S.J., Bartrons, R. Biochem. J. (1995) [Pubmed]
  10. Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21. Batra, R.S., Hatchwell, E., Rider, S., Brown, R., Brown, G.K., Craig, I.W. Genomics (1997) [Pubmed]
  11. Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. Manzano, A., Pérez, J.X., Nadal, M., Estivill, X., Lange, A., Bartrons, R. Gene (1999) [Pubmed]
  12. Improved Metabolic Stimulus for Glucose-Induced Insulin Secretion through GK and PFK-2/FBPase-2 Coexpression in Insulin-Producing RINm5F Cells. Baltrusch, S., Langer, S., Massa, L., Tiedge, M., Lenzen, S. Endocrinology (2006) [Pubmed]
  13. Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain. Kessler, R., Eschrich, K. Brain Res. Mol. Brain Res. (2001) [Pubmed]
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