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Kosloff, M. et al.

Substrate assisted catalysis -- application to G proteins.

The idea that both the substrate and the enzyme contribute to catalysis (substrate assisted catalysis; SAC) is applicable to guanine nucleotide-binding proteins (G proteins). Naturally occurring SAC uses GTP as a general base in the GTPase reaction catalyzed by G proteins. Engineered SAC has identified a putative rate-limiting step for the GTPase reaction and shown that GTPase-deficient oncogenic Ras mutants are not irreversibly impaired. Thus, anti-cancer drugs could potentially be designed to restore the blocked GTPase reaction.[1]

References

Substrate assisted catalysis -- application to G proteins. Kosloff, M., Selinger, Z. Trends Biochem. Sci. (2001) [Pubmed]

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