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Fagan, R. et al.

Fagan, Swindells, Overington, Weir,

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain.

Nicastrin, a protein implicated in Alzheimer's disease, has a domain that is found in the aminopeptidase/transferrin receptor superfamily. In nicastrin, this domain might possess catalytic activity (as observed with aminopeptidases) or it could serve merely as a binding domain (with analogy to the transferrin receptors) for the beta-amyloid precursor protein.[1]

References

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain. Fagan, R., Swindells, M., Overington, J., Weir, M. Trends Biochem. Sci. (2001) [Pubmed]

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