Gene Review:
TF - transferrin
Homo sapiens
Synonyms:
Beta-1 metal-binding globulin, PRO1400, PRO1557, PRO2086, Serotransferrin, ...
Feder,
Penny,
Irrinki,
Lee,
Lebrón,
Watson,
Tsuchihashi,
Sigal,
Bjorkman,
Schatzman,
Moirand,
Guyader,
Mendler,
Jouanolle,
Le Gall,
David,
Brissot,
Deugnier,
Fumeron,
Péan,
Driss,
Balkau,
Tichet,
Marre,
Grandchamp,
Efferth,
Benakis,
Romero,
Tomicic,
Rauh,
Steinbach,
Häfer,
Stamminger,
Oesch,
Kaina,
Marschall,
- The nature of extracellular iron influences iron acquisition by Mycobacterium tuberculosis residing within human macrophages. Olakanmi, O., Schlesinger, L.S., Ahmed, A., Britigan, B.E. Infect. Immun. (2004)
- The ability of gingival crevicular fluid acute phase proteins to distinguish healthy, gingivitis and periodontitis sites. Adonogianaki, E., Mooney, J., Kinane, D.F. Journal of clinical periodontology. (1992)
- Transferrin synthesis by small cell lung cancer cells acts as an autocrine regulator of cellular proliferation. Vostrejs, M., Moran, P.L., Seligman, P.A. J. Clin. Invest. (1988)
- A population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation. Gochee, P.A., Powell, L.W., Cullen, D.J., Du Sart, D., Rossi, E., Olynyk, J.K. Gastroenterology (2002)
- Hepatitis C, iron status, and disease severity: relationship with HFE mutations. Tung, B.Y., Emond, M.J., Bronner, M.P., Raaka, S.D., Cotler, S.J., Kowdley, K.V. Gastroenterology (2003)
- Differential susceptibility of transferrin glycoforms to chymotrypsin: a proteomics approach to the detection of carbohydrate-deficient transferrin. Valmu, L., Kalkkinen, N., Husa, A., Rye, P.D. Biochemistry (2005)
- HFE based re-evaluation of heterozygous hemochromatosis. Moirand, R., Guyader, D., Mendler, M.H., Jouanolle, A.M., Le Gall, J.Y., David, V., Brissot, P., Deugnier, Y. Am. J. Med. Genet. (2002)
- Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese. Zhang, P., Yang, Z., Zhang, C., Lu, Z., Shi, X., Zheng, W., Wan, C., Zhang, D., Zheng, C., Li, S., Jin, F., Wang, L. Neurosci. Lett. (2003)
- Effects of exercise on soluble transferrin receptor and other variables of the iron status. Schumacher, Y.O., Schmid, A., König, D., Berg, A. British journal of sports medicine. (2002)
- Disturbances in acute phase plasma proteins during melancholia: additional evidence for the presence of an inflammatory process during that illness. Maes, M., Scharpe, S., Bosmans, E., Vandewoude, M., Suy, E., Uyttenbroeck, W., Cooreman, W., Vandervorst, C., Raus, J. Prog. Neuropsychopharmacol. Biol. Psychiatry (1992)
- Molecular mechanisms of iron uptake in eukaryotes. de Silva, D.M., Askwith, C.C., Kaplan, J. Physiol. Rev. (1996)
- Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Lakadamyali, M., Rust, M.J., Zhuang, X. Cell (2006)
- Structure of the human transferrin receptor-transferrin complex. Cheng, Y., Zak, O., Aisen, P., Harrison, S.C., Walz, T. Cell (2004)
- Disease-related conditions in relatives of patients with hemochromatosis. Bulaj, Z.J., Ajioka, R.S., Phillips, J.D., LaSalle, B.A., Jorde, L.B., Griffen, L.M., Edwards, C.Q., Kushner, J.P. N. Engl. J. Med. (2000)
- A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain. Owen, D.J., Vallis, Y., Noble, M.E., Hunter, J.B., Dafforn, T.R., Evans, P.R., McMahon, H.T. Cell (1999)
- Two mechanisms of iron uptake from transferrin by melanoma cells. The effect of desferrioxamine and ferric ammonium citrate. Richardson, D., Baker, E. J. Biol. Chem. (1992)
- Ferritin and transferrin are both predictive of the onset of hyperglycemia in men and women over 3 years: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. Fumeron, F., Péan, F., Driss, F., Balkau, B., Tichet, J., Marre, M., Grandchamp, B. Diabetes Care (2006)
- Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron. Efferth, T., Benakis, A., Romero, M.R., Tomicic, M., Rauh, R., Steinbach, D., Häfer, R., Stamminger, T., Oesch, F., Kaina, B., Marschall, M. Free Radic. Biol. Med. (2004)
- Severity of AIDS and the response to EPO in uremia. Ifudu, O., Matthew, J.J., Mayers, J.D., Macey, L.J., Brezsnyak, W., Reydel, C., McClendon, E., Surgrue, T., Rao, S., Friedman, E.A. Am. J. Kidney Dis. (1997)
- Transferrin C2 variant does not confer a risk for Alzheimer's disease in Koreans. Kim, K.W., Jhoo, J.H., Lee, J.H., Lee, D.Y., Lee, K.U., Youn, J.Y., Woo, J.I. Neurosci. Lett. (2001)
- Immunostaining of transferrin and transferrin receptor in human seminiferous tubules. Vannelli, B.G., Orlando, C., Barni, T., Natali, A., Serio, M., Balboni, G.C. Fertil. Steril. (1986)
- Molecular analysis of the transferrin gene in a patient with hereditary hypotransferrinemia. Asada-Senju, M., Maeda, T., Sakata, T., Hayashi, A., Suzuki, T. J. Hum. Genet. (2002)
- Genetic linkage studies of transferrin, pseudocholinesterase, and chromosome 1 loci. Sparkes, R.S., Field, L.L., Sparkes, M.C., Crist, M., Spence, M.A., James, K., Garry, P.J. Hum. Hered. (1984)
- Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimer's disease in Koreans. Kim, K.W., Jhoo, J.H., Lee, J.H., Lee, K.U., Lee, D.Y., Youn, J.C., Youn, J.Y., Woo, J.I. Journal of neural transmission (Vienna, Austria : 1996) (2001)
- Effects of lactoferrin and its peptides on proliferation of rat intestinal epithelial cell line, IEC-18, in the presence of epidermal growth factor. Hagiwara, T., Shinoda, I., Fukuwatari, Y., Shimamura, S. Biosci. Biotechnol. Biochem. (1995)
- Intraphagosomal Mycobacterium tuberculosis acquires iron from both extracellular transferrin and intracellular iron pools. Impact of interferon-gamma and hemochromatosis. Olakanmi, O., Schlesinger, L.S., Ahmed, A., Britigan, B.E. J. Biol. Chem. (2002)
- Specificity of the lactoferrin and transferrin receptors in Neisseria gonorrhoeae. Lee, B.C., Schryvers, A.B. Mol. Microbiol. (1988)
- Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells. Georgopoulos, S., McKee, A., Kan, H.Y., Zannis, V.I. Biochemistry (2002)
- Activities derived from established human myeloid cell lines reverse the suppression of cell line colony formation by lactoferrin and transferrin. Broxmeyer, H.E., Rubin, B.Y., Berman, E., Juliano, L., Lu, L., Hast, L.J., Cooper, S., Singer, J.W. Exp. Hematol. (1986)
- A miniaturized agar culture system for cloning human erythropoietic progenitor cells. Konwalinka, G., Peschel, C., Boyd, J., Geissler, D., Ogriseg, M., Odavic, R., Braunsteiner, H. Exp. Hematol. (1984)
- Composition of pH-sensitive triad in C-lobe of human serum transferrin. Comparison to sequences of ovotransferrin and lactoferrin provides insight into functional differences in iron release. Halbrooks, P.J., Giannetti, A.M., Klein, J.S., Björkman, P.J., Larouche, J.R., Smith, V.C., MacGillivray, R.T., Everse, S.J., Mason, A.B. Biochemistry (2005)
- Gamma interferon induces colony-forming cells of the human monoblast cell line U937 to respond to inhibition by lactoferrin, transferrin, and acidic isoferritins. Broxmeyer, H.E., Piacibello, W., Juliano, L., Platzer, E., Berman, E., Rubin, B.Y. Exp. Hematol. (1986)
- The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Feder, J.N., Penny, D.M., Irrinki, A., Lee, V.K., Lebrón, J.A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P.J., Schatzman, R.C. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Release of the soluble transferrin receptor is directly regulated by binding of its ligand ferritransferrin. Dassler, K., Zydek, M., Wandzik, K., Kaup, M., Fuchs, H. J. Biol. Chem. (2006)
- Binding of lactoferrin and transferrin to the human promonocytic cell line U937. Effect on iron uptake and release. Ismail, M., Brock, J.H. J. Biol. Chem. (1993)
- Iron incorporation into apoferritin. The role of apoferritin as a ferroxidase. Bakker, G.R., Boyer, R.F. J. Biol. Chem. (1986)
- Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization. Lee, K.W., Liu, B., Ma, L., Li, H., Bang, P., Koeffler, H.P., Cohen, P. J. Biol. Chem. (2004)
- Diagnostic efficacy of screening tests for hereditary hemochromatosis. Borwein, S., Ghent, C.N., Valberg, L.S. Canadian Medical Association journal. (1984)
- Recombinant expression and functional characterization of human hephaestin: a multicopper oxidase with ferroxidase activity. Griffiths, T.A., Mauk, A.G., MacGillivray, R.T. Biochemistry (2005)
- ARF6 targets recycling vesicles to the plasma membrane: insights from an ultrastructural investigation. D'Souza-Schorey, C., van Donselaar, E., Hsu, V.W., Yang, C., Stahl, P.D., Peters, P.J. J. Cell Biol. (1998)
- Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells. Zacchi, P., Stenmark, H., Parton, R.G., Orioli, D., Lim, F., Giner, A., Mellman, I., Zerial, M., Murphy, C. J. Cell Biol. (1998)
- High density lipoprotein uptake by scavenger receptor SR-BII. Eckhardt, E.R., Cai, L., Sun, B., Webb, N.R., van der Westhuyzen, D.R. J. Biol. Chem. (2004)
- Clathrin box in G protein-coupled receptor kinase 2. Shiina, T., Arai, K., Tanabe, S., Yoshida, N., Haga, T., Nagao, T., Kurose, H. J. Biol. Chem. (2001)
- Transferrin receptor-dependent and -independent iron transport in gallium-resistant human lymphoid leukemic cells. Chitambar, C.R., Wereley, J.P. Blood (1998)
- HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells. Riedel, H.D., Muckenthaler, M.U., Gehrke, S.G., Mohr, I., Brennan, K., Herrmann, T., Fitscher, B.A., Hentze, M.W., Stremmel, W. Blood (1999)
- The acute-phase protein alpha 1-antitrypsin inhibits growth and proliferation of human early erythroid progenitor cells (burst-forming units-erythroid) and of human erythroleukemic cells (K562) in vitro by interfering with transferrin iron uptake. Graziadei, I., Gaggl, S., Kaserbacher, R., Braunsteiner, H., Vogel, W. Blood (1994)
- Diferric transferrin regulates transferrin receptor 2 protein stability. Johnson, M.B., Enns, C.A. Blood (2004)
- Serum prealbumin, retinol-binding protein, transferrin, and albumin levels in patients with large bowel cancer. Milano, G., Cooper, E.H., Goligher, J.C., Giles, G.R., Neville, A.M. J. Natl. Cancer Inst. (1978)
- Serum protein polymorphisms in four populations of Afghanistan. Rahimi, A.G., Goedde, H.W., Flatz, G., Kaifie, S., Benkmann, H.G., Delbrück, H. Am. J. Hum. Genet. (1977)
- Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia. Kozyraki, R., Fyfe, J., Verroust, P.J., Jacobsen, C., Dautry-Varsat, A., Gburek, J., Willnow, T.E., Christensen, E.I., Moestrup, S.K. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Hepcidin is decreased in TFR2 hemochromatosis. Nemeth, E., Roetto, A., Garozzo, G., Ganz, T., Camaschella, C. Blood (2005)
- Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells. You, K.R., Liu, M.J., Han, X.J., Lee, Z.W., Kim, D.G. Hepatology (2003)
- Highly enhanced fucosylation of serum glycoproteins in patients with hepatocellular carcinoma. Naitoh, A., Aoyagi, Y., Asakura, H. J. Gastroenterol. Hepatol. (1999)
- Ceruloplasmin is increased in cerebrospinal fluid in Alzheimer's disease but not Parkinson's disease. Loeffler, D.A., DeMaggio, A.J., Juneau, P.L., Brickman, C.M., Mashour, G.A., Finkelman, J.H., Pomara, N., LeWitt, P.A. Alzheimer disease and associated disorders. (1994)