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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Evaluation of a global screening assay for the investigation of the protein C anticoagulant pathway.

We have evaluated a global screening test for the protein C pathway, the 'ProC Global' (Dade Behring Ltd, Milton Keynes, UK). Patient groups tested included inherited protein C or S deficient and inherited/acquired activated protein C resistance. Results showed that protein C deficiencies and activated protein C resistance could be successfully detected with this test whereas deficiencies of protein S were less readily distinguished from the normal population. The ProC Global was unreliable in patients with antiphospholipid antibodies, raised plasma factor VIII:C and in those receiving oral anticoagulant therapy.[1]

References

  1. Evaluation of a global screening assay for the investigation of the protein C anticoagulant pathway. Rimmer, J.E., Cooper, P.C., Brookfield, C.J., Preston, F.E., Makris, M. Clinical and laboratory haematology. (2000) [Pubmed]
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