Disease relevance of sodium hypochlorite

• Finally, 19 patients with angiographic evidence of intracoronary thrombus were treated with local urokinase infusion with the Dispatch catheter either before or after balloon angioplasty or directional atherectomy [1].
• Two separate studies have been reported comparing Corynebacterium parvum and bacille Calmette-Guérin (BCG) as adjuvant immunotherapy for stage II melanoma patients (The Milton S. Hershey Medical Center, 48 patients; Southeastern Cancer Study Group [SECSG], 162 patients) [2].
• Myasthenia gravis and myotonic dystrophy in a 13-year-old girl. G. Milton Shy Award Essay, 1976 [3].
• A strain of Salmonella typhimurium isolated from a decubitus ulcer that was being treated topically with half-strength Dakin's solution became H2S negative, nitrate negative, and unable to produce gas from glucose [4].
• Aortas of cholesterol-fed NZW rabbits were balloon-denuded and intra-arterial gene transfer was performed using Dispatch catheter with Lp-PLA(2) or LacZ adenoviruses (1.15 x 10(10)pfu) [5].

Psychiatry related information on sodium hypochlorite

• Early psychiatry at Yale: Milton C. Winternitz and the founding of the Department of Psychiatry and Mental Hygiene [6].
• The Learning-Orientation Grade-Orientation Scale of Eison, Pollio, and Milton was administered to 85 college students and analyzed to study the psychometric properties of the instrument [7].
• Open University Press, Milton Keynes) and Locus of Control model (LC; Psychological Monographs, (1966) (80) in understanding the intention to use bicycle helmet use among bicycle helmet owners [8].
• Seeds of strategic and interactional psychotherapies: seminal contributions of Milton H. Erickson [9].
• Traditional psychoanalytic theories of infancy were challenged a number of years ago by Peterfreund (1978) and Milton Klein (1980), but published debate on this issue has only recently begun to appear [10].

High impact information on sodium hypochlorite

• We propose that Milton is a mitochondria-associated protein required for kinesin-mediated transport of mitochondria to nerve terminals [11].
• Milton protein is associated with mitochondria and is present primarily in axons and synapses [11].
• Photoreceptors mutant for milton show aberrant synaptic transmission despite normal phototransduction [11].
• Without Milton, synaptic terminals and axons lack mitochondria, although mitochondria are numerous in neuronal cell bodies [11].
• Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent [12].

Chemical compound and disease context of sodium hypochlorite

• BACKGROUND: Fragmin (Dalteparin, Pharmacia Ltd, Milton Keynes, UK), a low molecular weight heparin, is now recommended in the treatment of unstable angina [13].
• Therapeutic rounds at the Milton S. Hershey Medical Center: central nervous system toxicity caused by lidocaine [14].
• Decreasing the Clorox concentration to 10% still dechorionated eggs, but with reduced toxicity; substitution of a 10% solution of reagent-grade sodium hypochlorite for Clorox further decreased toxicity [15].
• Throughout his 50-year career, Dr. Milton Markowitz, former chairman of the department of pediatrics at the University of Connecticut School of Medicine, has been involved in these advances as an international expert on rheumatic fever prevention [16].
• Biolex, Shur-Clens, and Techni-Care were the least toxic to keratinocytes (toxicity index 0); hydrogen peroxide, modified Dakin's solution, and povidone (10%) were found to be the most toxic (toxicity index 100,000) [17].

Biological context of sodium hypochlorite

• Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein [11].
• These products, at the shorter times indicated for disinfection, and popular disinfectants, like Clorox, Cavicide, and Lysol were also studied [18].
• METHODS: All third-year students (n = 101) from academic years 1996-1998, who performed their obstetrics and gynecology clerkship at the Milton S [19].
• The hemostasis was monitored by Simplate (bioMérieux, Inc, Durham, NC) bleeding time and capillary closure time (platelet function analyzer PFA 100; Sysmex UK Ltd, Milton Keynes, United Kingdom) [20].
• Stent implantation in patient with visible intracoronary thrombus and compromised left ventricular function, after local thrombolysis using the Dispatch catheter [21].

Anatomical context of sodium hypochlorite

• In this issue Glater et al. demonstrate a new type of linkage through the adapter protein, milton, and the mitochondrial membrane GTPase, miro [22].
• Milton controls the early acquisition of mitochondria by Drosophila oocytes [23].
• METHODS: An anti-AP-1 decoy oligodeoxynucleotide (dODN) strategy was devised in which the dODN-containing solution (20 nmol) was administered locally through a Dispatch catheter into the coronary arteries of hypercholesterolemic minipigs at the time of PTCA (AVE-GFX stent) [24].
• CONCLUSION: Efficient arterial gene delivery to endothelial and superficial smooth muscle cells is feasible using local delivery of adenoviral vectors via the Dispatch autoperfusion catheter, in both normal and atheromatous arteries [25].
• The mechanism responsible for sodium-hypochlorite-induced reduction in dentin bond strength and its reversal with reducing agents is unknown [26].

Associations of sodium hypochlorite with other chemical compounds

• The recruitment of KHC to mitochondria is, in part, determined by the NH(2) terminus-splicing variant of milton [12].
• After Clorox digestion of human thyroids, calcium oxalate dihydrate was identified by x-ray diffraction and infrared spectroscopy [27].
• This study investigates the effects of sodium hypochlorite, or Dakin's solution (DS), on the function and viability of cells of the wound module (neutrophils, fibroblasts, and endothelial cells) [28].
• After stent deployment, L-arginine (600 mg/6 ml) or saline (6 ml) was locally delivered via the Dispatch catheter (Scimed) over 15 minutes [29].
• The chromatographic resolution of the four stereoisomers of carboxy-ibuprofen, a major metabolite of ibuprofen in man, was achieved using a Chiralpak AD chiral stationary phase (CSP) (J.T. Baker, Milton, Keynes, UK) [30].

Gene context of sodium hypochlorite

• Milton shares approximately 44% amino acid homology with GRIF-1 [31].
• We have evaluated a global screening test for the protein C pathway, the 'ProC Global' (Dade Behring Ltd, Milton Keynes, UK) [32].
• METHODS: PDE5 was isolated from the human platelet and PDE4 from the rat liver tissue using the FPLC system (Pharmacia, Milton Keynes, UK) and the Mono Q column [33].
• Two weeks later, the patency of the stented arteries was documented by coronary angiography, and the hRAD50 construct or empty vector mixed with lipid was delivered to one of the stented arteries in each pig using a Dispatch catheter [34].
• Objective: This retrospective study evaluated the appropriateness of requests assigned the alpha determinant at the time of dispatch by Emergency Medical Dispatchers using the Medical Priority Dispatch System (MPDS) [35].

Analytical, diagnostic and therapeutic context of sodium hypochlorite

• In vivo studies demonstrated immediate deposition of 0.12% of the urokinase delivered by the Dispatch catheter to the angioplasty site, compared with 0.0007% with systemic bolus, 0.003% with guiding catheter infusion, and 0.007% with local infusion with an end-hole catheter (P < .001) [1].
• Using a database of 30 ganzfeld and autoganzfeld studies, Milton and Wiseman's meta-analysis yielded an effect size (ES) of only 0.013 (Stouffer Z = 0.70, p = .24, one-tailed) [36].
• A retrospective study of 29 patients with invasive carcinoma of the vagina was completed at The Milton S [37].
• Twenty-seven patients with 76 pressure sores received treatment with hydrocolloid dressings (HCDs) and 25 patients with 52 pressure sores received treatment with Dakin's solution (chloramine-T)-soaked wet-to-dry dressings [38].
• We have investigated the use of sodium hypochloride (Clorox), in comparison to concentrated HCl, for PCR sterilization [39].

References