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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.

Extensive cDNA analysis demonstrated that all human and mouse protocadherin-beta genes are one-exon genes. The protein sequences of these genes are highly conserved, especially the three most membrane-proximal extracellular domains. Phylogenetic analysis suggested that this unique gene family evolved by duplication of one single protocadherin-beta gene to 15 copies. The final difference in the number of protocadherin-beta genes in man (#19) and mouse (#22) is probably caused by duplications later in evolution. The complex relationship between human and mouse genes and the lack of pseudogenes in the mouse protocadherin-beta gene cluster suggest a species-specific evolutionary pressure for maintenance of numerous protocadherin-beta genes.[1]

References

  1. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. Vanhalst, K., Kools, P., Vanden Eynde, E., van Roy, F. FEBS Lett. (2001) [Pubmed]
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