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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A helical lid converts a sulfotransferase to a dehydratase.

We report here the crystal structure of retinol dehydratase, an enzyme that catalyzes the synthesis of anhydroretinol. The enzyme is a member of the sulfotransferase superfamily and its crystal structure reveals the insertion of a helical lid into a canonical sulfotransferase fold. Site-directed mutations demonstrate that this inserted lid is necessary for anhydroretinol production but not for sulfonation; thus, insertion of a helical lid can convert a sulfotransferase into a dehydratase.[1]

References

  1. A helical lid converts a sulfotransferase to a dehydratase. Pakhomova, S., Kobayashi, M., Buck, J., Newcomer, M.E. Nat. Struct. Biol. (2001) [Pubmed]
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