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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The human contactin-associated protein-like 2 gene (CNTNAP2) spans over 2 Mb of DNA at chromosome 7q35.

Contactin-associated genes are members of the neurexin superfamily that encode a group of transmembrane proteins that mediate cell-cell interactions in the nervous system. To study the human contactin-associated protein-like 2 gene (CNTNAP2), we have determined its complete DNA sequence and its genomic organization to comprise 25 exons spanning greater than 2.0 Mb of DNA at 7q35. Our results indicate that CNTNAP2 encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome.[1]


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