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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7.

The hypoxia-inducible factor-1alpha (HIF-1alpha) is an important transcription factor for cellular responses to oxygen tension. It is rapidly degraded under normoxic conditions by the ubiquitin-dependent proteasome pathway. Here we report a critical role of the 20S proteasome subunit PSMA7 in HIF-1alpha regulation. PSMA7 was found to interact specifically with two subdomains of HIF-1alpha. PSMA7 inhibited the transactivation function of HIF-1alpha under both normoxic and hypoxia-mimicking conditions. In addition, we show that the PSMA7- mediated regulation of HIF-1alpha activity is associated with the proteasome pathway.[1]

References

  1. Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. Cho, S., Choi, Y.J., Kim, J.M., Jeong, S.T., Kim, J.H., Kim, S.H., Ryu, S.E. FEBS Lett. (2001) [Pubmed]
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