The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PSMA7  -  proteasome (prosome, macropain) subunit,...

Homo sapiens

Synonyms: C6, HSPC, Proteasome subunit RC6-1, Proteasome subunit XAPC7, Proteasome subunit alpha type-7, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PSMA7


High impact information on PSMA7

  • Interaction between c-Abl and Arg Tyrosine Kinases and Proteasome Subunit PSMA7 Regulates Proteasome Degradation [4].
  • We then showed that additional ribozymes directed against PSMA7 RNA inhibited HCV IRES activity in two assay systems: GCV resistance in the HeLa IRES TK reporter cell system and a transient transfection assay performed with a bicistronic Renilla-HCV IRES-firefly luciferase reporter in Huh7 cells [1].
  • It is important that the expression of NLS-defective XAPC7 also diminished the induction of resistance to etoposide and doxorubicin, typical topoisomerase II-directed drugs [5].
  • We found that the nuclear proteasome accumulation during glucose starvation was attenuated by stable expression of a mutant type of proteasome subunit, XAPC7, that lacked the nuclear localization signal (NLS) [5].
  • Additionally, transfection of PSMA7, a proteasome subunit, enhanced AR transactivation in a dose-dependent manner [6].

Biological context of PSMA7

  • PSMA7 inhibited the transactivation function of HIF-1alpha under both normoxic and hypoxia-mimicking conditions [7].
  • Combinations of PSMA7- and HuR-directed siRNAs with HCV-directed siRNAs revealed additive HCV RNA inhibitory effects in monocistronic replicon cells [8].
  • Several cell-permeable ceramide analogs (C2, C6, and C8), hydrolysis products of sphingomyelin, activated NF-kappaB less potently than neutral SMase, but had no effect on NOx production [9].
  • The C-6 hydroxy and C-7 methyl groups were introduced via a silyl conjugate addition followed by the Tamao oxidation and Donohoe methylation, respectively, in a highly stereoselective manner [10].
  • The aim of this study was to evaluate the synthetic C6 peptide test as a first-line test in a two-tiered scheme for Borrelia serology in a clinically well-characterized population of patients with Lyme borreliosis in Kalmar County, Sweden [2].

Anatomical context of PSMA7

  • In addition to HSPC, horse seminal plasma contained a group of three electrophoretically distinguishable proteinase inhibitors, corresponding roughly to a Mr of 6500 [11].

Associations of PSMA7 with chemical compounds

  • We have identified the 20S proteasomal subunit alpha4 (synonyms: PSMA7, XAPC7, subunit alpha type 7) as a new interacting partner of parkin [12].
  • The specific compressibility and additive PP values for the mixture of matrix lipid (EPC or HSPC), cholesterol, and PEG-DSPE for all liposome compositions investigated reached their maximum at 7+/-2 mol% PEG-DSPE, the concentration of PEG-DSPE at which the highest biological stability of the LUV is achieved [13].
  • Transmembrane electrochemical gradients of H+ or ammonium sulfate were created, and their effect on the uptake of fasudil into preformed hydrogenated soy phosphatidylcholine/cholesterol (HSPC/CHOL) liposomes were examined [14].
  • The best lipid matrices resulted from hydrogenated phosphatidylcholine from soybean (HSPC): Cholesterol (Chol): distearoyl-phosphatidylglycerol (DSPG) (molar ratio 2:2:1) prepared with BNZ dissolved in DMSO [15].
  • The molecule C6 has long reorientation times in n-decane solvent as compared to methanol over all temperatures [16].

Physical interactions of PSMA7


Other interactions of PSMA7

  • In addition, we show that the PSMA7-mediated regulation of HIF-1alpha activity is associated with the proteasome pathway [7].
  • Here we demonstrate that PSMC1, an ATPase-like subunit of the 19 S proteasome component, also interacts with HBX and PSMA7 [17].

Analytical, diagnostic and therapeutic context of PSMA7


  1. Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation. Krüger, M., Beger, C., Welch, P.J., Barber, J.R., Manns, M.P., Wong-Staal, F. Mol. Cell. Biol. (2001) [Pubmed]
  2. C6 peptide ELISA test in the serodiagnosis of Lyme borreliosis in Sweden. Tjernberg, I., Kr??ger, G., Eliasson, I. Eur. J. Clin. Microbiol. Infect. Dis. (2007) [Pubmed]
  3. Immunocytochemical detection of the homeobox B3, B4, and C6 gene products in childhood medulloblastomas/primitive neuroectodermal tumors. Bodey, B., Bodey, B., Siegel, S.E., Kaiser, H.E. Anticancer Res. (2000) [Pubmed]
  4. Interaction between c-Abl and Arg Tyrosine Kinases and Proteasome Subunit PSMA7 Regulates Proteasome Degradation. Liu, X., Huang, W., Li, C., Li, P., Yuan, J., Li, X., Qiu, X.B., Ma, Q., Cao, C. Mol. Cell (2006) [Pubmed]
  5. Nuclear localization of proteasomes participates in stress-inducible resistance of solid tumor cells to topoisomerase II-directed drugs. Ogiso, Y., Tomida, A., Tsuruo, T. Cancer Res. (2002) [Pubmed]
  6. Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells. Lin, H.K., Altuwaijri, S., Lin, W.J., Kan, P.Y., Collins, L.L., Chang, C. J. Biol. Chem. (2002) [Pubmed]
  7. Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. Cho, S., Choi, Y.J., Kim, J.M., Jeong, S.T., Kim, J.H., Kim, S.H., Ryu, S.E. FEBS Lett. (2001) [Pubmed]
  8. Inhibition of hepatitis C virus translation and subgenomic replication by siRNAs directed against highly conserved HCV sequence and cellular HCV cofactors. Korf, M., Jarczak, D., Beger, C., Manns, M.P., Krüger, M. J. Hepatol. (2005) [Pubmed]
  9. Role of nuclear factor-kappaB activation in cytokine- and sphingomyelinase-stimulated inducible nitric oxide synthase gene expression in vascular smooth muscle cells. Katsuyama, K., Shichiri, M., Marumo, F., Hirata, Y. Endocrinology (1998) [Pubmed]
  10. Catalytic asymmetric total synthesis of (+)-lactacystin. Fukuda, N., Sasaki, K., Sastry, T.V., Kanai, M., Shibasaki, M. J. Org. Chem. (2006) [Pubmed]
  11. Proteinase inhibitors of horse seminal plasma. A high molecular mass, acid-soluble proteinase inhibitor. von Fellenberg, R., Zweifel, H.R., Grünig, G., Pellegrini, A. Biol. Chem. Hoppe-Seyler (1985) [Pubmed]
  12. Parkin interacts with the proteasome subunit alpha4. Dächsel, J.C., Lücking, C.B., Deeg, S., Schultz, E., Lalowski, M., Casademunt, E., Corti, O., Hampe, C., Patenge, N., Vaupel, K., Yamamoto, A., Dichgans, M., Brice, A., Wanker, E.E., Kahle, P.J., Gasser, T. FEBS Lett. (2005) [Pubmed]
  13. Effect of grafted PEG on liposome size and on compressibility and packing of lipid bilayer. Garbuzenko, O., Barenholz, Y., Priev, A. Chem. Phys. Lipids (2005) [Pubmed]
  14. Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes. Ishida, T., Takanashi, Y., Doi, H., Yamamoto, I., Kiwada, H. International journal of pharmaceutics. (2002) [Pubmed]
  15. Development and in vitro characterisation of a benznidazole liposomal formulation. Morilla, M.J., Benavidez, P., Lopez, M.O., Bakas, L., Romero, E.L. International journal of pharmaceutics. (2002) [Pubmed]
  16. Rotational diffusion and solvatochromic correlation of coumarin 6 laser dye. Raikar, U.S., Renuka, C.G., Nadaf, Y.F., Mulimani, B.G., Karguppikar, A.M. Journal of fluorescence (2006) [Pubmed]
  17. Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex. Zhang, Z., Torii, N., Furusaka, A., Malayaman, N., Hu, Z., Liang, T.J. J. Biol. Chem. (2000) [Pubmed]
  18. Predicting kidney graft failure using time-dependent renal function covariates. de Bruijne, M.H., Sijpkens, Y.W., Paul, L.C., Westendorp, R.G., van Houwelingen, H.C., Zwinderman, A.H. Journal of clinical epidemiology. (2003) [Pubmed]
  19. Evaluation of the C6 enzyme-linked immunoadsorbent assay for the serodiagnosis of Lyme borreliosis in north-eastern Italy. Cinco, M., Murgia, R. New Microbiol. (2006) [Pubmed]
WikiGenes - Universities