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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A new verdict for an old convict.

Certain human cancers and carcinogen-induced rodent tumors commonly contain Kras2 mutations. This activated form of ras has always been described as a dominant oncogene. A new study indicates that wildtype Kras2 has properties of a tumor suppressor gene and may have the capacity to reduce the transforming potential of oncogenically activated ras.[1]


  1. A new verdict for an old convict. Pfeifer, G.P. Nat. Genet. (2001) [Pubmed]
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