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Kammerl, M.C. et al.

Kammerl, Nüsing, Schweda, Endemann, Stubanus, Kees, Lackner, Fischereder, Krämer,

Low sodium and furosemide-induced stimulation of the renin system in man is mediated by cyclooxygenase 2.

The aim of this study was to examine the effects of highly selective inhibition of cyclooxygenase 2 ( COX-2) with rofecoxib on the renin system during long-term stimulation and after short-term stimulation. Six healthy male volunteers received, in a randomized crossover design, a low-sodium diet for days 1 through 9 with or without 25 mg rofecoxib twice daily on days 5 through 9 and, in addition, 20 mg of furosemide intravenously on day 8. Plasma renin activity increased 2 to 3 times over baseline with a low-sodium diet and 5 times over baseline 30 minutes after intravenous furosemide; it was still elevated nearly 5 times on day 9. These effects were completely blocked by rofecoxib. Plasma aldosterone and urinary aldosterone concentrations basically reflected the findings with plasma renin activity. Urinary sodium excretion decreased during a low-sodium diet and increased after intravenous furosemide without being significantly affected by rofecoxib. We have concluded that low-sodium and furosemide-stimulated renin and aldosterone secretion is completely blocked in healthy volunteers during COX-2 inhibition with rofecoxib, suggesting that intact COX-2 is of major importance for stimulation of the renin system under these conditions in man.[1]

References

Low sodium and furosemide-induced stimulation of the renin system in man is mediated by cyclooxygenase 2. Kammerl, M.C., Nüsing, R.M., Schweda, F., Endemann, D., Stubanus, M., Kees, F., Lackner, K.J., Fischereder, M., Krämer, B.K. Clin. Pharmacol. Ther. (2001) [Pubmed]

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