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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Sequence analysis of the rat phenylalanine hydroxylase gene promoter.

We have characterized the 5'-end (3218 bp) of the rat phenylalanine hydroxylase (PAH) gene. Within this PAH promoter sequence, we have identified a number of putative regulatory sites analogous to those present in the human and murine PAH promoters. In particular, potential HNF 1 binding sites and a CRE have been identified. These sequences respectively bind HNF1 and CREB transcription factors present in rat nuclear extracts and may be significant in the tissue-specific and hormonal control of PAH expression.[1]


  1. Sequence analysis of the rat phenylalanine hydroxylase gene promoter. Rees, D., Fisher, M.J., McDowall, I.L. DNA Seq. (2001) [Pubmed]
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