The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Prenatal cocaine exposure disrupts non-spatial, short-term memory in adolescent and adult male rats.

The rise in the recreational use of cocaine in the last two decades has resulted in a growing health concern about fetal drug exposure. In exposed children, investigators have noted altered cognitive performance in complex or distracting, but not more controlled, situations. In rodent models, deficits in short-term memory have been noted in some, but not all, paradigms, although these studies also differ in routes of administration and dosing models. Here, we report short-term memory deficits in rats prenatally exposed to cocaine using an intravenous administration model to closer mimic cocaine doses and pharmacokinetics seen with human use. A spontaneous two object recognition task was used to avoid (1) clearly aversive or rewarding components, (2) reference memory component and (3) the use of external motivators, such as swimming stress or food deprivation/rewards. In this task, adolescent and adult male rats exposed to cocaine in utero demonstrated deficits in short-term memory compared with saline controls. No difference in the time spent exploring the objects or the number of failures was noted between the prenatal cocaine and saline rats. This study suggests that prenatal exposure to cocaine can result in a long-lasting deficit in non-spatial, short-term memory in a spontaneously performed task.[1]


  1. Prenatal cocaine exposure disrupts non-spatial, short-term memory in adolescent and adult male rats. Morrow, B.A., Elsworth, J.D., Roth, R.H. Behav. Brain Res. (2002) [Pubmed]
WikiGenes - Universities