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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Short total synthesis of (+)-madindolines A and B.

[reaction: see text] A short and efficient total synthesis of (+)-madindolines A (1) and B (2), potent and selective inhibitors of interleukin 6, has been achieved. The synthesis features a key chelation-controlled 1,4-diastereoselective acylation to generate the quaternary carbon and an intramolecular acylation of allylsilane to build up the cyclopentene unit.[1]

References

  1. Short total synthesis of (+)-madindolines A and B. Hirose, T., Sunazuka, T., Shirahata, T., Yamamoto, D., Harigaya, Y., Kuwajima, I., Omura, S. Org. Lett. (2002) [Pubmed]
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