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Kono, K. et al.

Kono, Takahashi, Amemiya, Ichihara, Sugai, Iizuka, Fujii, Matsumoto,

Frequencies of HER-2/neu overexpression relating to HLA haplotype in patients with gastric cancer.

We have identified that HER-2/neu-derived peptides are naturally processed as tumor rejection antigens recognized by tumor-specific, HLA-A2-restricted cytotoxic T lymphocytes in gastric cancer. To evaluate candidates for immunotherapy using HER-2/neu-derived, HLA-A2-restricted peptides, we examined the frequency of HLA-A2 relating to HER-2/neu overexpression or the infiltrating grade of tumor-infiltrating lymphocytes (TILs) in Japanese patients with gastric cancer. HER-2/neu-overexpressing tumors detected by immunohistochemistry amounted to 19% of primary gastric cancers and HLA-A2-positive patients with gastric cancer were 31% of primary gastric-cancer cases. Finally, gastric-cancer patients with both HLA-A2-positive and HER-2/neu-overexpressing tumors amounted to 6.6% of these cases. There was no significant difference in the infiltrating grade of TILs between gastric cancers overexpressing HER-2/neu and those that did not. The candidate for HER-2/neu-based immunotherapy with HLA-A2-restricted peptides represent a very limited population of Japanese patients.[1]

References

Frequencies of HER-2/neu overexpression relating to HLA haplotype in patients with gastric cancer. Kono, K., Takahashi, A., Amemiya, H., Ichihara, F., Sugai, H., Iizuka, H., Fujii, H., Matsumoto, Y. Int. J. Cancer (2002) [Pubmed]

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