Gene Review:
ERBB2 - erb-b2 receptor tyrosine kinase 2
Homo sapiens
Synonyms:
CD340, HER-2, HER-2/neu, HER2, MLN 19, ...
Lindsey Maccoux,
Wong,
Marshall,
Schraml,
Rennstam,
Heinz Kölbl,
Moch,
Tanner,
Kononen,
Christian F. Singer,
Wiebke Schormann,
Jonathan West,
Braselmann,
Eva-Maria Fuchs,
Chamness,
Hilsenbeck,
Farmer,
Evgenia Freis,
Specht,
Katja Ickstadt,
Marcus Schmidt,
Bardou,
Gernot Hudelist,
Holger Schwender,
Silvia Selinski,
Daphne Gschwantler-Kaulich,
Martin,
Walch,
Ali,
Ernst Kubista,
Anneliese Fink-Retter,
Allred,
Clark,
Höfler,
Jan Georg Hengstler,
Mihatsch,
Siewert,
Martin Schuler,
Isola,
Adrover,
Esther Fieber,
Niveiro,
Margarethe Rudas,
Marc Brulport,
Osborne,
Fuqua,
Johnston,
Stein,
Michael Gnant,
Peiró,
Schiff,
Dowsett,
Susanne Gebhard,
Hopt,
Aranda,
Pay??,
Ilka Brigitte Petry,
Segu??,
Hopp,
Baldetorp,
Bubendorf,
Matthias Hermes,
Jörg Rahnenführer,
Wolfgang Köstler,
Kallioniemi,
Kytölä,
Sauter,
Nocito,
Wolfgang Lamm,
Bissig,
Klaus Czerwenka,
Werner,
Alenda,
Mathias Gehrmann,
- Repeated observation of breast tumor subtypes in independent gene expression data sets. Sorlie, T., Tibshirani, R., Parker, J., Hastie, T., Marron, J.S., Nobel, A., Deng, S., Johnsen, H., Pesich, R., Geisler, S., Demeter, J., Perou, C.M., Lønning, P.E., Brown, P.O., Børresen-Dale, A.L., Botstein, D. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene. D'souza, B., Taylor-Papadimitriou, J. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272. Shimamura, T., Ji, H., Minami, Y., Thomas, R.K., Lowell, A.M., Shah, K., Greulich, H., Glatt, K.A., Meyerson, M., Shapiro, G.I., Wong, K.K. Cancer Res. (2006)
- Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays. Bubendorf, L., Kononen, J., Koivisto, P., Schraml, P., Moch, H., Gasser, T.C., Willi, N., Mihatsch, M.J., Sauter, G., Kallioniemi, O.P. Cancer Res. (1999)
- ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma. Hernan, R., Fasheh, R., Calabrese, C., Frank, A.J., Maclean, K.H., Allard, D., Barraclough, R., Gilbertson, R.J. Cancer Res. (2003)
- Protein kinase Calpha determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification. Magnifico, A., Albano, L., Campaner, S., Campiglio, M., Pilotti, S., Ménard, S., Tagliabue, E. Cancer Res. (2007)
- Radiation effects on development of HER2-positive breast carcinomas. Castiglioni, F., Terenziani, M., Carcangiu, M.L., Miliano, R., Aiello, P., Bertola, L., Triulzi, T., Gasparini, P., Camerini, T., Sozzi, G., Fossati-Bellani, F., Ménard, S., Tagliabue, E. Clin. Cancer Res. (2007)
- Incomplete surgical resection of ductal carcinomas in situ results in activation of ERBB2 in residual breast cancer cells. Singer, C.F., Hudelist, G., Fuchs, E.M., Köstler, W., Fink-Retter, A., Gschwantler-Kaulich, D., Gnant, M., Lamm, W., Rudas, M., Czerwenka, K., Kubista, E. Endocr. Relat. Cancer (2009)
- Micro-SPECT/CT with 111In-DTPA-pertuzumab sensitively detects trastuzumab-mediated HER2 downregulation and tumor response in athymic mice bearing MDA-MB-361 human breast cancer xenografts. McLarty, K., Cornelissen, B., Cai, Z., Scollard, D.A., Costantini, D.L., Done, S.J., Reilly, R.M. J. Nucl. Med. (2009)
- Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial. Riethdorf, S., Müller, V., Zhang, L., Rau, T., Loibl, S., Komor, M., Roller, M., Huober, J., Fehm, T., Schrader, I., Hilfrich, J., Holms, F., Tesch, H., Eidtmann, H., Untch, M., von Minckwitz, G., Pantel, K. Clin. Cancer Res. (2010)
- Analysis of HER2 by chromogenic in situ hybridization and immunohistochemistry in lymph node-negative breast carcinoma: prognostic relevance. Peir??, G., Aranda, F.I., Adrover, E., Niveiro, M., Alenda, C., Pay??, A., Segu??, J. Hum. Pathol. (2007)
- The oncoproteins c-erb-B2, c-fos and the tumour suppressor protein p53 in human embryos and fetuses. Miosge, N., Schneider, W., Götz, W., Herken, R. Anat. Embryol. (1997)
- Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor alpha in NIH 3T3 cells. Hudziak, R.M., Lewis, G.D., Shalaby, M.R., Eessalu, T.E., Aggarwal, B.B., Ullrich, A., Shepard, H.M. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Murine monoclonal anti-idiotypic antibody as a surrogate antigen for human Her-2/neu. Baral, R., Sherrat, A., Das, R., Foon, K.A., Bhattacharya-Chatterjee, M. Int. J. Cancer (2001)
- From the molecule to the clinic--inhibiting HER2 to treat breast cancer. Eisenhauer, E.A. N. Engl. J. Med. (2001)
- Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells. Peles, E., Bacus, S.S., Koski, R.A., Lu, H.S., Wen, D., Ogden, S.G., Levy, R.B., Yarden, Y. Cell (1992)
- Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer. van de Vijver, M.J., Peterse, J.L., Mooi, W.J., Wisman, P., Lomans, J., Dalesio, O., Nusse, R. N. Engl. J. Med. (1988)
- PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Shin, I., Yakes, F.M., Rojo, F., Shin, N.Y., Bakin, A.V., Baselga, J., Arteaga, C.L. Nat. Med. (2002)
- Gene expression profiling of primary breast carcinomas using arrays of candidate genes. Bertucci, F., Houlgatte, R., Benziane, A., Granjeaud, S., Adélaïde, J., Tagett, R., Loriod, B., Jacquemier, J., Viens, P., Jordan, B., Birnbaum, D., Nguyen, C. Hum. Mol. Genet. (2000)
- Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells. Trost, T.M., Lausch, E.U., Fees, S.A., Schmitt, S., Enklaar, T., Reutzel, D., Brixel, L.R., Schmidtke, P., Maringer, M., Schiffer, I.B., Heimerdinger, C.K., Hengstler, J.G., Fritz, G., Bockamp, E.O., Prawitt, D., Zabel, B.U., Spangenberg, C. Cancer Res. (2005)
- Medulloblastoma sensitivity to 17-allylamino-17-demethoxygeldanamycin requires MEK/ERKM. Calabrese, C., Frank, A., Maclean, K., Gilbertson, R. J. Biol. Chem. (2003)
- The CGA gene as new predictor of the response to endocrine therapy in ER alpha-positive postmenopausal breast cancer patients. Bièche, I., Parfait, B., Noguès, C., Andrieu, C., Vidaud, D., Spyratos, F., Lidereau, R., Vidaud, M. Oncogene (2001)
- Coamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett's carcinoma. Walch, A., Specht, K., Braselmann, H., Stein, H., Siewert, J.R., Hopt, U., Höfler, H., Werner, M. Int. J. Cancer (2004)
- Differential expression of proliferation-associated molecules in individual micrometastatic carcinoma cells. Pantel, K., Schlimok, G., Braun, S., Kutter, D., Lindemann, F., Schaller, G., Funke, I., Izbicki, J.R., Riethmüller, G. J. Natl. Cancer Inst. (1993)
- Inverse regulation of human ERBB2 and epidermal growth factor receptors by tumor necrosis factor alpha. Kalthoff, H., Roeder, C., Gieseking, J., Humburg, I., Schmiegel, W. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Sørlie, T., Perou, C.M., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M.B., van de Rijn, M., Jeffrey, S.S., Thorsen, T., Quist, H., Matese, J.C., Brown, P.O., Botstein, D., Eystein Lønning, P., Børresen-Dale, A.L. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Chromosomal rearrangements and oncogene amplification precede aneuploidization in the genetic evolution of breast cancer. Rennstam, K., Baldetorp, B., Kytölä, S., Tanner, M., Isola, J. Cancer Res. (2001)
- Tissue microarrays for gene amplification surveys in many different tumor types. Schraml, P., Kononen, J., Bubendorf, L., Moch, H., Bissig, H., Nocito, A., Mihatsch, M.J., Kallioniemi, O.P., Sauter, G. Clin. Cancer Res. (1999)
- Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2. Rio, M.C., Bellocq, J.P., Gairard, B., Rasmussen, U.B., Krust, A., Koehl, C., Calderoli, H., Schiff, V., Renaud, R., Chambon, P. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation. Martin, L.A., Farmer, I., Johnston, S.R., Ali, S., Marshall, C., Dowsett, M. J. Biol. Chem. (2003)
- Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Wang, L., Schulz, T.C., Sherrer, E.S., Dauphin, D.S., Shin, S., Nelson, A.M., Ware, C.B., Zhan, M., Song, C.Z., Chen, X., Brimble, S.N., McLean, A., Galeano, M.J., Uhl, E.W., D'Amour, K.A., Chesnut, J.D., Rao, M.S., Blau, C.A., Robins, A.J. Blood (2007)
- The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1alpha/CXCL12. Kishimoto, H., Wang, Z., Bhat-Nakshatri, P., Chang, D., Clarke, R., Nakshatri, H. Carcinogenesis (2005)
- Interaction between Erbin and a Catenin-related protein in epithelial cells. Jaulin-Bastard, F., Arsanto, J.P., Le Bivic, A., Navarro, C., Vély, F., Saito, H., Marchetto, S., Hatzfeld, M., Santoni, M.J., Birnbaum, D., Borg, J.P. J. Biol. Chem. (2002)
- Identification of HTF (HER2 transcription factor) as an AP-2 (activator protein-2) transcription factor and contribution of the HTF binding site to ERBB2 gene overexpression. Vernimmen, D., Begon, D., Salvador, C., Gofflot, S., Grooteclaes, M., Winkler, R. Biochem. J. (2003)
- Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds. Danilenko, D.M., Ring, B.D., Lu, J.Z., Tarpley, J.E., Chang, D., Liu, N., Wen, D., Pierce, G.F. J. Clin. Invest. (1995)
- Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma. Peles, E., Levy, R.B., Or, E., Ullrich, A., Yarden, Y. EMBO J. (1991)
- Characterization of topoisomerase II alpha gene amplification and deletion in breast cancer. Järvinen, T.A., Tanner, M., Bärlund, M., Borg, A., Isola, J. Genes Chromosomes Cancer (1999)
- Dual blockade of EGFR and ERK1/2 phosphorylation potentiates growth inhibition of breast cancer cells. Lev, D.C., Kim, L.S., Melnikova, V., Ruiz, M., Ananthaswamy, H.N., Price, J.E. Br. J. Cancer (2004)
- PEA3 cooperates with c-Jun in regulation of HER2/neu transcription. Matsui, K., Sugimori, K., Motomura, H., Ejiri, N., Tsukada, K., Kitajima, I. Oncol. Rep. (2006)
- HER-2/c-erbB2 is phosphorylated by calmodulin-dependent protein kinase II on a single site in the cytoplasmic tail at threonine-1172. Feinmesser, R.L., Gray, K., Means, A.R., Chantry, A. Oncogene (1996)
- Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer. Konecny, G., Pauletti, G., Pegram, M., Untch, M., Dandekar, S., Aguilar, Z., Wilson, C., Rong, H.M., Bauerfeind, I., Felber, M., Wang, H.J., Beryt, M., Seshadri, R., Hepp, H., Slamon, D.J. J. Natl. Cancer Inst. (2003)
- Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer. Osborne, C.K., Bardou, V., Hopp, T.A., Chamness, G.C., Hilsenbeck, S.G., Fuqua, S.A., Wong, J., Allred, D.C., Clark, G.M., Schiff, R. J. Natl. Cancer Inst. (2003)
- Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. Su, J.L., Shih, J.Y., Yen, M.L., Jeng, Y.M., Chang, C.C., Hsieh, C.Y., Wei, L.H., Yang, P.C., Kuo, M.L. Cancer Res. (2004)
- Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility. Ueda, Y., Wang, S., Dumont, N., Yi, J.Y., Koh, Y., Arteaga, C.L. J. Biol. Chem. (2004)
- Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation. Zhou, X., Agazie, Y.M. J. Biol. Chem. (2009)
- ERBB2 induces an antiapoptotic expression pattern of Bcl-2 family members in node-negative breast cancer. Petry, I.B., Fieber, E., Schmidt, M., Gehrmann, M., Gebhard, S., Hermes, M., Schormann, W., Selinski, S., Freis, E., Schwender, H., Brulport, M., Ickstadt, K., Rahnenführer, J., Maccoux, L., West, J., Kölbl, H., Schuler, M., Hengstler, J.G. Clin. Cancer Res. (2010)
- Heregulin induces tyrosine phosphorylation of HER4/p180erbB4. Plowman, G.D., Green, J.M., Culouscou, J.M., Carlton, G.W., Rothwell, V.M., Buckley, S. Nature (1993)
- P-glycoprotein, HER-2/neu, and mutant p53 expression in human gynecologic tumors. Schneider, J., Rubio, M.P., Barbazán, M.J., Rodriguez-Escudero, F.J., Seizinger, B.R., Castresana, J.S. J. Natl. Cancer Inst. (1994)
- New amplified and highly expressed genes discovered in the ERBB2 amplicon in breast cancer by cDNA microarrays. Kauraniemi, P., Bärlund, M., Monni, O., Kallioniemi, A. Cancer Res. (2001)
- Amplification of a 280-kilobase core region at the ERBB2 locus leads to activation of two hypothetical proteins in breast cancer. Kauraniemi, P., Kuukasjärvi, T., Sauter, G., Kallioniemi, A. Am. J. Pathol. (2003)
- Identification and validation of an ERBB2 gene expression signature in breast cancers. Bertucci, F., Borie, N., Ginestier, C., Groulet, A., Charafe-Jauffret, E., Adélaïde, J., Geneix, J., Bachelart, L., Finetti, P., Koki, A., Hermitte, F., Hassoun, J., Debono, S., Viens, P., Fert, V., Jacquemier, J., Birnbaum, D. Oncogene (2004)