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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effects of thyroid hormone on mRNAs of phosphoglycerate mutase subunits in rat muscle during development.

BACKGROUND: We previously showed that triiodothyronine (T3) stimulates muscle phosphoglycerate mutase (PGAM) activity and isozyme transition in rat skeletal and cardiac muscles. METHODS: The effects of T3 on PGAM types B and M subunit expression in rat muscle during development are reported. RESULTS: T3 administration during the first 21 days of rat life more than doubles type M PGAM mRNA levels, but produces minor effects on type B PGAM mRNA levels. The antihormone propylthiouracil (PTU) slightly decreases both type B and M mRNA levels, but this decrease is not statistically significant. CONCLUSION: Thyroid hormone influences PGAM mRNA isozyme levels differently and increases type M mRNA.[1]

References

  1. Effects of thyroid hormone on mRNAs of phosphoglycerate mutase subunits in rat muscle during development. González-Cinca, N., Gonzalo, S., Ascaso, C., Carreras, J., Climent, F. Horm. Res. (2002) [Pubmed]
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