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Chemical Compound Review

propylthiouracil     6-propyl-2-sulfanylidene-1H- pyrimidin-4-one

Synonyms: Procasil, Propacil, Propycil, Prothycil, Prothyran, ...
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Disease relevance of Tegretol


Psychiatry related information on Tegretol


High impact information on Tegretol


Chemical compound and disease context of Tegretol


Biological context of Tegretol


Anatomical context of Tegretol


Associations of Tegretol with other chemical compounds


Gene context of Tegretol

  • The wt and mutant D2 enzymes are essentially insensitive to propylthiouracil [concentration inhibiting 50% of activity (IC(50)) > 2 mM] in the presence of 20 mM DTT, but when tested in the presence of 0.2 mM DTT the IC(50) value for propylthiouracil is reduced to about 0.1 mM [34].
  • TR beta PV mice treated with 6-propyl-2-thiouracil and supplemented with T3 to make them euthyroid have decreased contractility with negative and positive rates of relaxation and contraction as well as peak systolic pressure diminished by 35 +/- 5, 34 +/- 6, and 35 +/- 6% in comparison with WT mice [35].
  • Compared to euthyroid thyrotrophs, the beta-1,4-galactosyltransferase mRNA level in thyrotrophs increased 440% after mice received PTU for 1 week; the mean increase within thyrotrophs over the 6-week period was 173%, whereas there was little change in corticotrophs [36].
  • During cerebellar development, an approximately 3-fold increase in the cerebellar content of ROR alpha messenger RNA (mRNA) was seen in both propylthiouracil-treated, and propylthiouracil-treated and T4-replaced animals [37].
  • Compared to euthyroid thyrotrophs, the alpha-mannosidase-II mRNA level in thyrotrophs remained unchanged while mice received PTU for 4 weeks, but then increased 150% after week 6 of PTU treatment [36].

Analytical, diagnostic and therapeutic context of Tegretol


  1. Neonatal thyroid function after propylthiouracil therapy for maternal Graves' disease. Cheron, R.G., Kaplan, M.M., Larsen, P.R., Selenkow, H.A., Crigler, J.F. N. Engl. J. Med. (1981) [Pubmed]
  2. Long-term treatment of alcoholic liver disease with propylthiouracil. Orrego, H., Blake, J.E., Blendis, L.M., Compton, K.V., Israel, Y. N. Engl. J. Med. (1987) [Pubmed]
  3. Adrenergic activation of triiodothyronine production in brown adipose tissue. Silva, J.E., Larsen, P.R. Nature (1983) [Pubmed]
  4. Propylthiouracil-induced cutaneous vasculitis. Case presentation and review of the literature. Vasily, D.B., Tyler, W.B. JAMA (1980) [Pubmed]
  5. Propylthiouracil-induced agranulocytosis in four patients previously treated with the drug. Shiran, A., Shechner, C., Dickstein, G. JAMA (1991) [Pubmed]
  6. Propylthiouracil levels in hyperthyroid patients unresponsive to large doses. Evidence of poor patient compliance. Cooper, D.S. Ann. Intern. Med. (1985) [Pubmed]
  7. 6-n-Propylthiouracil: a genetic marker for taste, with implications for food preference and dietary habits. Tepper, B.J. Am. J. Hum. Genet. (1998) [Pubmed]
  8. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Bufe, B., Breslin, P.A., Kuhn, C., Reed, D.R., Tharp, C.D., Slack, J.P., Kim, U.K., Drayna, D., Meyerhof, W. Curr. Biol. (2005) [Pubmed]
  9. Children's food preferences and genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP). Anliker, J.A., Bartoshuk, L., Ferris, A.M., Hooks, L.D. Am. J. Clin. Nutr. (1991) [Pubmed]
  10. Long-term treatment of alcoholic liver disease with propylthiouracil. Part 2: Influence of drop-out rates and of continued alcohol consumption in a clinical trial. Orrego, H., Blake, J.E., Blendis, L.M., Compton, K.V., Volpe, R., Israel, Y. J. Hepatol. (1994) [Pubmed]
  11. Antithyroid drug therapy for Graves' disease during pregnancy. Optimal regimen for fetal thyroid status. Momotani, N., Noh, J., Oyanagi, H., Ishikawa, N., Ito, K. N. Engl. J. Med. (1986) [Pubmed]
  12. A family of candidate taste receptors in human and mouse. Matsunami, H., Montmayeur, J.P., Buck, L.B. Nature (2000) [Pubmed]
  13. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Berry, M.J., Banu, L., Larsen, P.R. Nature (1991) [Pubmed]
  14. Bitter taste of saccharin related to the genetic ability to taste the bitter substance 6-n-propylthiouracil. Bartoshuk, L.M. Science (1979) [Pubmed]
  15. Mechanism of the protective effect of propylthiouracil against acetaminophen (Tylenol) toxicity in the rat. Linscheer, W.G., Raheja, K.L., Cho, C., Smith, N.J. Gastroenterology (1980) [Pubmed]
  16. Experimental alcohol-induced hepatic necrosis: suppression by propylthiouracil. Israel, Y., Kalant, H., Orrego, H., Khanna, J.M., Videla, L., Phillips, J.M. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  17. Increased survival of rats bearing Morris hepatoma 7800 after induction of hypothyroidism. Mishkin, S., Morris, H.P., Yalovsky, M.A., Narasimha Murthy, P.V. Cancer Res. (1979) [Pubmed]
  18. Developing cholinergic basal forebrain neurons are sensitive to thyroid hormone. Gould, E., Butcher, L.L. J. Neurosci. (1989) [Pubmed]
  19. Inhibition of experimentally induced cirrhosis in rats by hypothyroidism. Oren, R., Dotan, I., Papa, M., Marravi, Y., Aeed, H., Barg, J., Zeidel, L., Bruck, R., Halpern, Z. Hepatology (1996) [Pubmed]
  20. Evidence for two pathways of iodothyronine 5'-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. Visser, T.J., Kaplan, M.M., Leonard, J.L., Larsen, P.R. J. Clin. Invest. (1983) [Pubmed]
  21. Development of the ipsilateral retinothalamic projection in the frog Xenopus laevis. III. The role of thyroxine. Hoskins, S.G., Grobstein, P. J. Neurosci. (1985) [Pubmed]
  22. Effect of propylthiouracil on the ethanol-induced increase in liver oxygen consumption in awake rats. Carmichael, F.J., Orrego, H., Saldivia, V., Israel, Y. Hepatology (1993) [Pubmed]
  23. Effects of propylthiouracil and methimazole on splanchnic hemodynamics in awake and unrestrained rats. Kawasaki, T., Carmichael, F.J., Giles, G., Saldivia, V., Israel, Y., Orrego, H. Hepatology (1989) [Pubmed]
  24. Graves' disease in pregnancy years after hypothyroidism with recurrent passive-transfer neonatal Graves' disease in offspring. Therapeutic considerations. Volpé, R., Ehrlich, R., Steiner, G., Row, V.V. Am. J. Med. (1984) [Pubmed]
  25. Effect on exophthalmos of various methods of treatment of Graves' disease. Gwinup, G., Elias, A.N., Ascher, M.S. JAMA (1982) [Pubmed]
  26. Effects of diethylstilbestrol and propylthiouracil on the rat pituitary. An immunohistochemical and ultrastructural study. Lloyd, R.V., Mailloux, J. J. Natl. Cancer Inst. (1987) [Pubmed]
  27. Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil. Mihas, A.A., Holley, P., Koff, R.S., Hirschowitz, B.I. Gastroenterology (1976) [Pubmed]
  28. Propylthiouracil in human milk. Revision of a dogma. Kampmann, J.P., Johansen, K., Hansen, J.M., Helweg, J. Lancet (1980) [Pubmed]
  29. Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex. Visser, T.J., Leonard, J.L., Kaplan, M.M., Larsen, P.R. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  30. Thyroid hormone induction of keratin genes: a two-step activation of gene expression during development. Mathisen, P.M., Miller, L. Genes Dev. (1987) [Pubmed]
  31. Direct protection against acetaminophen hepatotoxicity by propylthiouracil. In vivo and in vitro studies in rats and mice. Yamada, T., Ludwig, S., Kuhlenkamp, J., Kaplowitz, N. J. Clin. Invest. (1981) [Pubmed]
  32. Antithyroid drugs and release of inflammatory mediators by complement-attacked thyroid cells. Weetman, A.P., Tandon, N., Morgan, B.P. Lancet (1992) [Pubmed]
  33. Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus. Koller, K.J., Wolff, R.S., Warden, M.K., Zoeller, R.T. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  34. Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor. Kuiper, G.G., Klootwijk, W., Visser, T.J. Endocrinology (2002) [Pubmed]
  35. Cardiac expression and function of thyroid hormone receptor beta and its PV mutant. Swanson, E.A., Gloss, B., Belke, D.D., Kaneshige, M., Cheng, S.Y., Dillmann, W.H. Endocrinology (2003) [Pubmed]
  36. Beta-1,4-galactosyltransferase and alpha-mannosidase-II messenger ribonucleic acid levels increase with different kinetics in thyrotrophs of hypothyroid mice. Helton, T.E., Magner, J.A. Endocrinology (1994) [Pubmed]
  37. ROR alpha gene expression in the perinatal rat cerebellum: ontogeny and thyroid hormone regulation. Koibuchi, N., Chin, W.W. Endocrinology (1998) [Pubmed]
  38. Inhibition of the growth of Morris hepatoma No. 44 in rats after induction of hypothyroidism: evidence that Morris hepatomas are thyroid dependent. Mishkin, S., Morris, H.P., Yalovsky, M.A., Murthy, P.V. Gastroenterology (1979) [Pubmed]
  39. Thyroid hormones in alcoholic liver disease. Effect of treatment with 6-n-propylthiouracil. Israel, Y., Walfish, P.G., Orrego, H., Blake, J., Kalant, H. Gastroenterology (1979) [Pubmed]
  40. Hepatic injury during propylthiouracil therapy in patients with hyperthyroidism. A cohort study. Liaw, Y.F., Huang, M.J., Fan, K.D., Li, K.L., Wu, S.S., Chen, T.J. Ann. Intern. Med. (1993) [Pubmed]
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