Identification and characterization of murine IRAK-M.
Interleukin-1 receptor-associated-kinases (IRAKs) are signal transduction mediators of the Toll/IL-1 receptor family, which comprise several transmembrane proteins involved in host defense mechanisms. Today four different human IRAKs (hu- IRAK-1, hu-IRAK-2, hu- IRAK-M, hu-IRAK-4) and two murine IRAKs (mouse pelle like kinase (mPLK) and mu-IRAK-4) have been described. Here we report the identification and characterization of murine IRAK-M (mu- IRAK-M), a mouse homologue to human IRAK-M (hu- IRAK-M). These IRAK-M molecules show 71% sequence identity, a comparable cellular expression, and functional similarities with respect to signal transduction capacity and kinase activity, suggesting functional homology in signalling in human and mouse cells.[1]References
- Identification and characterization of murine IRAK-M. Rosati, O., Martin, M.U. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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