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MeSH Review

Signal Transduction

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Disease relevance of Signal Transduction


Psychiatry related information on Signal Transduction


High impact information on Signal Transduction

  • A shared feature of signal transduction downstream of most receptors on immune cells, as in nonhematopoietic cell types, is the activation of phosphoinositide 3-kinase (PI3K) [11].
  • Chemokine messages are decoded by specific receptors that initiate signal transduction events leading to a multitude of cellular responses, leukocyte chemotaxis and adhesion in particular [12].
  • The FcalphaRI alpha chain lacks canonical signal transduction domains but can associate with the FcR gamma-chain that bears an activation motif (ITAM) in the cytoplasmic domain, allowing activatory functions [13].
  • The CIS family of proteins (also referred to as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines [14].
  • Studies of signal transduction have begun to determine the basis for the coreceptor activities of CD19 [15].

Chemical compound and disease context of Signal Transduction


Biological context of Signal Transduction


Anatomical context of Signal Transduction


Associations of Signal Transduction with chemical compounds

  • The mechanisms by which these inhibitors of cytokine signal transduction exert their effects have been extensively studied and will provide useful information for regulating tyrosine-kinase activity [14].
  • Multiple mechanisms of androgen independence have now been documented, including amplification of the androgen receptor as well as signal transduction pathways that bypass the androgen receptor completely [30].
  • Most prokaryotic signal-transduction systems and a few eukaryotic pathways use phosphotransfer schemes involving two conserved components, a histidine protein kinase and a response regulator protein [31].
  • Highly enriched in brain tissue and present throughout the body, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is central to the coordination and execution of Ca(2+) signal transduction [32].
  • As a serine/threonine protein phosphatase, calcineurin participates in a number of cellular processes and Ca(2+)-dependent signal transduction pathways [33].

Gene context of Signal Transduction


Analytical, diagnostic and therapeutic context of Signal Transduction


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  2. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Xu, Y., Tao, X., Shen, B., Horng, T., Medzhitov, R., Manley, J.L., Tong, L. Nature (2000) [Pubmed]
  3. The role of prolactin in mammary carcinoma. Clevenger, C.V., Furth, P.A., Hankinson, S.E., Schuler, L.A. Endocr. Rev. (2003) [Pubmed]
  4. Androgen receptor in prostate cancer. Heinlein, C.A., Chang, C. Endocr. Rev. (2004) [Pubmed]
  5. HIV-1-infected T cells show a selective signaling defect after perturbation of CD3/antigen receptor. Linette, G.P., Hartzman, R.J., Ledbetter, J.A., June, C.H. Science (1988) [Pubmed]
  6. Inositol monophosphatase--a putative target for Li+ in the treatment of bipolar disorder. Atack, J.R., Broughton, H.B., Pollack, S.J. Trends Neurosci. (1995) [Pubmed]
  7. Impaired fungicide activity in plants blocked in disease resistance signal transduction. Molina, A., Hunt, M.D., Ryals, J.A. Plant Cell (1998) [Pubmed]
  8. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Lambert, M.P., Barlow, A.K., Chromy, B.A., Edwards, C., Freed, R., Liosatos, M., Morgan, T.E., Rozovsky, I., Trommer, B., Viola, K.L., Wals, P., Zhang, C., Finch, C.E., Krafft, G.A., Klein, W.L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  9. Phosphorylation of mitogen-activated protein kinase by one-trial and multi-trial classical conditioning. Crow, T., Xue-Bian, J.J., Siddiqi, V., Kang, Y., Neary, J.T. J. Neurosci. (1998) [Pubmed]
  10. On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models. Galdzicki, Z., Siarey, R., Pearce, R., Stoll, J., Rapoport, S.I. Brain Res. Brain Res. Rev. (2001) [Pubmed]
  11. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Deane, J.A., Fruman, D.A. Annu. Rev. Immunol. (2004) [Pubmed]
  12. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Rot, A., von Andrian, U.H. Annu. Rev. Immunol. (2004) [Pubmed]
  13. IgA Fc receptors. Monteiro, R.C., Van De Winkel, J.G. Annu. Rev. Immunol. (2003) [Pubmed]
  14. Negative regulation of cytokine signaling pathways. Yasukawa, H., Sasaki, A., Yoshimura, A. Annu. Rev. Immunol. (2000) [Pubmed]
  15. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Fearon, D.T., Carroll, M.C. Annu. Rev. Immunol. (2000) [Pubmed]
  16. Coexistence of guanylate cyclase and atrial natriuretic factor receptor in a 180-kD protein. Paul, A.K., Marala, R.B., Jaiswal, R.K., Sharma, R.K. Science (1987) [Pubmed]
  17. Inhibition of T cell receptor signal transduction by tyrosine kinase-interacting protein of Herpesvirus saimiri. Cho, N.H., Feng, P., Lee, S.H., Lee, B.S., Liang, X., Chang, H., Jung, J.U. J. Exp. Med. (2004) [Pubmed]
  18. Mast cell tryptase is a mitogen for cultured fibroblasts. Ruoss, S.J., Hartmann, T., Caughey, G.H. J. Clin. Invest. (1991) [Pubmed]
  19. Activation of skeletal muscle casein kinase II by insulin is not diminished in subjects with insulin resistance. Maeda, R., Raz, I., Zurlo, F., Sommercorn, J. J. Clin. Invest. (1991) [Pubmed]
  20. mTOR and cancer: reason for dancing at the crossroads? Thomas, G.V. Curr. Opin. Genet. Dev. (2006) [Pubmed]
  21. Neuronal Ca2+/calmodulin-dependent protein kinases. Hanson, P.I., Schulman, H. Annu. Rev. Biochem. (1992) [Pubmed]
  22. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Jackson-Grusby, L., Beard, C., Possemato, R., Tudor, M., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E., Jaenisch, R. Nat. Genet. (2001) [Pubmed]
  23. FAR1 links the signal transduction pathway to the cell cycle machinery in yeast. Peter, M., Gartner, A., Horecka, J., Ammerer, G., Herskowitz, I. Cell (1993) [Pubmed]
  24. Germline KRAS mutations cause Noonan syndrome. Schubbert, S., Zenker, M., Rowe, S.L., Böll, S., Klein, C., Bollag, G., van der Burgt, I., Musante, L., Kalscheuer, V., Wehner, L.E., Nguyen, H., West, B., Zhang, K.Y., Sistermans, E., Rauch, A., Niemeyer, C.M., Shannon, K., Kratz, C.P. Nat. Genet. (2006) [Pubmed]
  25. Down-regulation of the Drosophila morphogen bicoid by the torso receptor-mediated signal transduction cascade. Ronchi, E., Treisman, J., Dostatni, N., Struhl, G., Desplan, C. Cell (1993) [Pubmed]
  26. CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Trowbridge, I.S., Thomas, M.L. Annu. Rev. Immunol. (1994) [Pubmed]
  27. Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Hicke, L., Riezman, H. Cell (1996) [Pubmed]
  28. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Chung, J., Kuo, C.J., Crabtree, G.R., Blenis, J. Cell (1992) [Pubmed]
  29. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. Paloneva, J., Kestilä, M., Wu, J., Salminen, A., Böhling, T., Ruotsalainen, V., Hakola, P., Bakker, A.B., Phillips, J.H., Pekkarinen, P., Lanier, L.L., Timonen, T., Peltonen, L. Nat. Genet. (2000) [Pubmed]
  30. Advances in prostate cancer chemotherapy: a new era begins. Pienta, K.J., Smith, D.C. CA: a cancer journal for clinicians. (2005) [Pubmed]
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  32. Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function. Hudmon, A., Schulman, H. Annu. Rev. Biochem. (2002) [Pubmed]
  33. Calcineurin: form and function. Rusnak, F., Mertz, P. Physiol. Rev. (2000) [Pubmed]
  34. The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Sugamura, K., Asao, H., Kondo, M., Tanaka, N., Ishii, N., Ohbo, K., Nakamura, M., Takeshita, T. Annu. Rev. Immunol. (1996) [Pubmed]
  35. Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. MacDonald, T.J., Brown, K.M., LaFleur, B., Peterson, K., Lawlor, C., Chen, Y., Packer, R.J., Cogen, P., Stephan, D.A. Nat. Genet. (2001) [Pubmed]
  36. The human interferon alpha/beta receptor: characterization and molecular cloning. Novick, D., Cohen, B., Rubinstein, M. Cell (1994) [Pubmed]
  37. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Wiegmann, K., Schütze, S., Machleidt, T., Witte, D., Krönke, M. Cell (1994) [Pubmed]
  38. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Vaisse, C., Halaas, J.L., Horvath, C.M., Darnell, J.E., Stoffel, M., Friedman, J.M. Nat. Genet. (1996) [Pubmed]
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  40. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Kumar, T.R., Wang, Y., Lu, N., Matzuk, M.M. Nat. Genet. (1997) [Pubmed]
  41. Gigantism in mice lacking suppressor of cytokine signalling-2. Metcalf, D., Greenhalgh, C.J., Viney, E., Willson, T.A., Starr, R., Nicola, N.A., Hilton, D.J., Alexander, W.S. Nature (2000) [Pubmed]
  42. Molecular cloning and complete amino-acid sequence of form-I phosphoinositide-specific phospholipase C. Bennett, C.F., Balcarek, J.M., Varrichio, A., Crooke, S.T. Nature (1988) [Pubmed]
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