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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mururins A-C, three new lignoids from Brosimum acutifolium and their protein kinase inhibitory activity.

Two new flavonolignans, mururins A and B ( 1 and 2), and a new lignan, mururin C ( 3), were isolated from the bark of Brosimum acutifolium Huber together with three known lignans. Their structures were elucidated by spectroscopic means and chemical modifications. They were tested for protein kinase A (PKA) and protein kinase C (PKC) inhibitory activity. Mururin A showed 3 % and 63 % inhibition to PKA and PKC, respectively, at 20 microM. Mururin B showed 58 % and 38 % inhibition, respectively. Mururin C did not have significant activity.[1]

References

  1. Mururins A-C, three new lignoids from Brosimum acutifolium and their protein kinase inhibitory activity. Takashima, J., Asano, S., Ohsaki, A. Planta Med. (2002) [Pubmed]
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