- Mutations in a novel gene, TMIE, are associated with hearing loss linked to the DFNB6 locus. Naz, S., Giguere, C.M., Kohrman, D.C., Mitchem, K.L., Riazuddin, S., Morell, R.J., Ramesh, A., Srisailpathy, S., Deshmukh, D., Riazuddin, S., Griffith, A.J., Friedman, T.B., Smith, R.J., Wilcox, E.R. Am. J. Hum. Genet. (2002)