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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?

A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum.[1]


  1. TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains? Winter, E., Ponting, C.P. Trends Biochem. Sci. (2002) [Pubmed]
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