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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Higher LDL oxidation at rest and after a rugby game in weekend warriors.

BACKGROUND/AIM: Weekend warriors (WW), people who only exercise vigorously once a week, are a fast-growing population. The present study investigates LDL oxidation and activities of antioxidant enzymes in WW (n = 6) at rest and after a rugby game. The results are compared with those of sedentary controls (CON, n = 10) and trained rugby players (TR, n = 15). METHODS: LDL + VLDL conjugated dienes (CD) and thiobarbituric acid reactive substances (TBARS) as well as erythrocyte superoxide dismutase (SOD) and glutathione peroxidase ( GPx) activities were analyzed in WW and TR groups before and after a rugby game. RESULTS: The WW showed higher LDL+VLDL CD and TBARS levels than TR and CON groups at rest (p < 0.05). LDL+VLDL CD and TBARS were also significantly higher in the WW group than in the TR group after exercise (p < 0.05). Both WW and TR groups showed significant exercise-induced elevations in LDL+VLDL TBARS (p < 0.05), with the WW having higher degrees of increase (15.8 +/- 7.9 vs. 6.3 +/- 9.0%, WW group vs. TR group; p < 0.05). Erythrocyte SOD and GPx activities at rest were similar in all three groups. CONCLUSION: These results suggest that WW may have a higher LDL oxidation than TR and CON persons at rest and higher exercise-induced LDL oxidation levels than TR athletes.[1]


  1. Higher LDL oxidation at rest and after a rugby game in weekend warriors. Chang, C.K., Tseng, H.F., Hsuuw, Y.D., Chan, W.H., Shieh, L.C. Ann. Nutr. Metab. (2002) [Pubmed]
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