- Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice. Wilding, J., Straub, J., Bee, J., Churchman, M., Bodmer, W., Dickson, C., Tomlinson, I., Ilyas, M. Cancer Res. (2002)