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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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LAG1 puts the focus on ceramide signaling.

Longevity-assurance gene 1 ( LAG 1) is a yeast longevity gene. Homologues of the Lag 1 protein can be found throughout phylogeny, although sequence similarity is very limited. The Lag 1 protein is located in the endoplasmic reticulum (ER), where it helps to accelerate the transport of glycosylphosphatidylinositol (GPI)-anchored proteins to the Golgi. This function of Lag 1 p results from its participation in ceramide synthesis. Thus, Lag 1 p and its homologues are likely to play a role in ceramide signaling, which affects growth, proliferation, stress resistance, and apoptosis. This provides a wide range of physiologic processes through which Lag 1 p may impinge upon life span.[1]

References

  1. LAG1 puts the focus on ceramide signaling. Jazwinski, S.M., Conzelmann, A. Int. J. Biochem. Cell Biol. (2002) [Pubmed]
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