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Gene Review

CERS1  -  ceramide synthase 1

Homo sapiens

Synonyms: CerS1, Ceramide synthase 1, LAG1, LAG1 longevity assurance homolog 1, LASS1, ...
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Disease relevance of LASS1

  • Using a baculovirus vector expression system, we found that a 10 kDa recombinant LAG-1 protein is secreted by AcNPV infected SF9 cells, as determined in Western blot experiments by the reactivity of specific anti-peptidic heteroantibodies [1].

High impact information on LASS1


Other interactions of LASS1


  1. Cloning and expression of a lymphocyte activation gene (LAG-1). Baixeras, E., Roman-Roman, S., Jitsukawa, S., Genevee, C., Mechiche, S., Viegas-Pequignot, E., Hercend, T., Triebel, F. Mol. Immunol. (1990) [Pubmed]
  2. LAG1 puts the focus on ceramide signaling. Jazwinski, S.M., Conzelmann, A. Int. J. Biochem. Cell Biol. (2002) [Pubmed]
  3. Cloning and characterization of a LASS1-GDF1 transcript in rat cerebral cortex: conservation of a bicistronic structure. Wang, B., Shi, G., Fu, Y., Xu, X. DNA Seq. (2007) [Pubmed]
  4. Expression of LASS2 controlled by LAG1 or ADH1 promoters cannot functionally complement Lag1p. Yu, Y., Lu, H., Pan, H., Ma, J.H., Ding, Z.J., Li, Y.Y. Microbiol. Res. (2006) [Pubmed]
  5. Molecular cloning, characterisation and tissue-specific expression of human LAG3, a member of the novel Lag1 protein family. Cai, X.F., Tao, Z., Yan, Z.Q., Yang, S.L., Gong, Y. DNA Seq. (2003) [Pubmed]
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