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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Pitfalls in cefepime titration from human plasma: plasma- and temperature-related drug degradation in vitro.

While developing a high-pressure liquid chromatography assay for cefepime in plasma, we observed significant drug degradation at 20 and 37 degrees C but not at 4 degrees C. This plasma-related degradation persisted after protein removal. This warrants caution regarding cefepime assays for pharmacokinetic and pharmacodynamic studies of cefepime in vitro and in vivo.[1]

References

  1. Pitfalls in cefepime titration from human plasma: plasma- and temperature-related drug degradation in vitro. Bugnon, D., Giannoni, E., Majcherczyk, P., Glauser, M.P., Moreillon, P. Antimicrob. Agents Chemother. (2002) [Pubmed]
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