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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A diffusion tensor MRI study of basal ganglia from patients with ADEM.

Using diffusion tensor (DT) MRI and histogram analysis, we measured mean diffusivity ((-)D) of basal ganglia grey matter (GM) from eight patients with acute disseminated encephalomyelitis (ADEM), 10 patients with multiple sclerosis ( MS), and 10 healthy controls. Patients with ADEM had higher average (-)D (p=0.02) and lower (-)D histogram peak height (p=0.008) of the basal ganglia GM than patients with MS. Microscopic tissue damage occurs in the basal ganglia of ADEM patients, but not in MS patients with a similar burden of MRI-visible brain lesions.[1]


  1. A diffusion tensor MRI study of basal ganglia from patients with ADEM. Holtmannspötter, M., Inglese, M., Rovaris, M., Rocca, M.A., Codella, M., Filippi, M. J. Neurol. Sci. (2003) [Pubmed]
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