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MeSH Review

Basal Ganglia

 
 
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Disease relevance of Basal Ganglia

 

Psychiatry related information on Basal Ganglia

 

High impact information on Basal Ganglia

 

Chemical compound and disease context of Basal Ganglia

 

Biological context of Basal Ganglia

 

Anatomical context of Basal Ganglia

  • The distribution of NPY was different from that of any other peptide system described, being particularly concentrated in the basal ganglia, amygdala and nucleus accumbens [26].
  • Although the HPRT gene is normally constitutively expressed in all tissues at low levels, expression is elevated approximately fourfold in several regions of the central nervous system, particularly in the basal ganglia [27].
  • The D2 site is largely restricted to the striatal complex (caudate-putamen, nucleus accumbens septi, and olfactory tubercle), whereas the S2 site is enriched in layer 5 of motor cortex, the perirhinal and cingulate cortices, and the claustrum [28].
  • The basal ganglia are thought to modulate the release or inhibition of movements by way of direct and indirect pathways that act as a push-pull system of cortico-basal ganglia circuits [29].
  • BDNF mRNA-expressing cells were more widely distributed in the rat brain, with high levels in neurons of CA2, CA3, and the hilar region of the dentate gyrus, in the external and internal pyramidal layers of the cerebral cortex, in the claustrum, and in one brainstem structure [30].
 

Associations of Basal Ganglia with chemical compounds

  • Dopamine visualized in the basal ganglia of living man [31].
  • DARPP-32 (dopamine- and cyclic-AMP-regulated phosphoprotein of molecular weight 32,000) is a neuronal phosphoprotein that displays a regional distribution in the mammalian brain very similar to that of dopamine-containing nerve terminals, being highly concentrated in the basal ganglia [32].
  • By 3 months, glucose metabolic activity had increased in the parietal, temporal, and occipital cortices and the basal ganglia, with subsequent increases in frontal and various association regions occurring by 8 months [33].
  • Expression of the D1 and D2 receptors for dopamine was reduced in the ventral striatum of mutant mice, and the response of double null mutant mice to cocaine, which affects dopamine signaling in the mesolimbic system, was blunted [34].
  • Reduced leucine-enkephalin--like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure [35].
 

Gene context of Basal Ganglia

 

Analytical, diagnostic and therapeutic context of Basal Ganglia

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