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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Usefulness of AgNOR counts in diagnosing epithelial dysplasia.

BACKGROUND: Diagnosis of epithelial dysplasia has traditionally been subjective, and there is a need for a quantifiable and useful test. METHODS: In a double blind study, clinical leukoplakias from 52 people were diagnosed for presence ( DLK) or absence (NDLK) of epithelial dysplasia using hematoxylin and eosin (H&E) stain as a gold standard criterion, and results were compared against their mean silver stainable nucleolar organizer region (AgNOR) counts. We used mean AgNOR count cut-point of 2.37 from our prior report as the diagnostic threshold (mean >or= 2.37 being DLK and mean < 2.37 being NDLK). RESULTS: The two methods (H&E and AgNOR) disagreed in 37% of the diagnoses. Both NDLK and DLK had high AgNOR counts. P-AgNOR was non-contributory for diagnosing epithelial dysplasia. CONCLUSIONS: Mean AgNOR count can be a useful tool in definitive diagnosis of epithelial dysplasia.[1]


  1. Usefulness of AgNOR counts in diagnosing epithelial dysplasia. Ray, J.G., Chattopadhyay, A., Caplan, D.J. J. Oral Pathol. Med. (2003) [Pubmed]
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