The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Double-Blind Method

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Double-Blind Method


Psychiatry related information on Double-Blind Method


High impact information on Double-Blind Method

  • METHODS: In a double-blind study, patients were randomly assigned to postoperative administration of one of five daily doses of Org31540/SR90107A, given once daily, or to 30 mg of enoxaparin, given every 12 hours [11].
  • METHODS: A total of 1513 patients were enrolled in this randomized, double-blind study comparing losartan (50 to 100 mg once daily) with placebo, both taken in addition to conventional antihypertensive treatment (calcium-channel antagonists, diuretics, alpha-blockers, beta-blockers, and centrally acting agents), for a mean of 3.4 years [12].
  • Those who responded to treatment then entered a double-blind study and were randomly assigned to receive either placebo or etanercept for four months or until a flare of the disease occurred [13].
  • In a randomized, double-blind study, we compared lorazepam with placebo for the prevention of recurrent seizures related to alcohol [14].
  • We randomly assigned 762 patients to receive dofetilide, a novel class III antiarrhythmic agent, and 756 to receive placebo in a double-blind study [15].

Chemical compound and disease context of Double-Blind Method


Biological context of Double-Blind Method


Anatomical context of Double-Blind Method


Associations of Double-Blind Method with chemical compounds


Gene context of Double-Blind Method


Analytical, diagnostic and therapeutic context of Double-Blind Method


  1. Transdermal nicotine for active ulcerative colitis. Pullan, R.D., Rhodes, J., Ganesh, S., Mani, V., Morris, J.S., Williams, G.T., Newcombe, R.G., Russell, M.A., Feyerabend, C., Thomas, G.A. N. Engl. J. Med. (1994) [Pubmed]
  2. A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism. Kearon, C., Gent, M., Hirsh, J., Weitz, J., Kovacs, M.J., Anderson, D.R., Turpie, A.G., Green, D., Ginsberg, J.S., Wells, P., MacKinnon, B., Julian, J.A. N. Engl. J. Med. (1999) [Pubmed]
  3. A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. Douglas, J.M., Critchlow, C., Benedetti, J., Mertz, G.J., Connor, J.D., Hintz, M.A., Fahnlander, A., Remington, M., Winter, C., Corey, L. N. Engl. J. Med. (1984) [Pubmed]
  4. Acenocoumarol and heparin compared with acenocoumarol alone in the initial treatment of proximal-vein thrombosis. Brandjes, D.P., Heijboer, H., Büller, H.R., de Rijk, M., Jagt, H., ten Cate, J.W. N. Engl. J. Med. (1992) [Pubmed]
  5. Hormonal therapy of cryptorchidism. A randomized, double-blind study comparing human chorionic gonadotropin and gonadotropin-releasing hormone. Rajfer, J., Handelsman, D.J., Swerdloff, R.S., Hurwitz, R., Kaplan, H., Vandergast, T., Ehrlich, R.M. N. Engl. J. Med. (1986) [Pubmed]
  6. Treatment of Gilles de la Tourette's syndrome with clonidine and neuroleptics. Shapiro, A.K., Shapiro, E., Eisenkraft, G.J. Arch. Gen. Psychiatry (1983) [Pubmed]
  7. Lithium carbonate and affective disorders. V: A double-blind study of prophylaxis of depression in bipolar illness. Dunner, D.L., Stallone, F., Fieve, R.R. Arch. Gen. Psychiatry (1976) [Pubmed]
  8. Clomipramine treatment of agoraphobic women. An eight-week controlled trial. Johnston, D.G., Troyer, I.E., Whitsett, S.F. Arch. Gen. Psychiatry (1988) [Pubmed]
  9. Low incidence of persistent tardive dyskinesia in elderly patients with dementia treated with risperidone. Jeste, D.V., Okamoto, A., Napolitano, J., Kane, J.M., Martinez, R.A. The American journal of psychiatry. (2000) [Pubmed]
  10. A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania. Keck, P.E., Marcus, R., Tourkodimitris, S., Ali, M., Liebeskind, A., Saha, A., Ingenito, G. The American journal of psychiatry. (2003) [Pubmed]
  11. A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement. Turpie, A.G., Gallus, A.S., Hoek, J.A. N. Engl. J. Med. (2001) [Pubmed]
  12. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. Brenner, B.M., Cooper, M.E., de Zeeuw, D., Keane, W.F., Mitch, W.E., Parving, H.H., Remuzzi, G., Snapinn, S.M., Zhang, Z., Shahinfar, S. N. Engl. J. Med. (2001) [Pubmed]
  13. Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. Lovell, D.J., Giannini, E.H., Reiff, A., Cawkwell, G.D., Silverman, E.D., Nocton, J.J., Stein, L.D., Gedalia, A., Ilowite, N.T., Wallace, C.A., Whitmore, J., Finck, B.K. N. Engl. J. Med. (2000) [Pubmed]
  14. Lorazepam for the prevention of recurrent seizures related to alcohol. D'Onofrio, G., Rathlev, N.K., Ulrich, A.S., Fish, S.S., Freedland, E.S. N. Engl. J. Med. (1999) [Pubmed]
  15. Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group. Torp-Pedersen, C., Møller, M., Bloch-Thomsen, P.E., Køber, L., Sandøe, E., Egstrup, K., Agner, E., Carlsen, J., Videbaek, J., Marchant, B., Camm, A.J. N. Engl. J. Med. (1999) [Pubmed]
  16. Retrolental fibroplasia: efficacy of vitamin E in a double-blind clinical study of preterm infants. Hittner, H.M., Godio, L.B., Rudolph, A.J., Adams, J.M., Garcia-Prats, J.A., Friedman, Z., Kautz, J.A., Monaco, W.A. N. Engl. J. Med. (1981) [Pubmed]
  17. Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis. Storm, T., Thamsborg, G., Steiniche, T., Genant, H.K., Sørensen, O.H. N. Engl. J. Med. (1990) [Pubmed]
  18. Ursodiol for primary sclerosing cholangitis. Mayo Primary Sclerosing Cholangitis-Ursodeoxycholic Acid Study Group. Lindor, K.D. N. Engl. J. Med. (1997) [Pubmed]
  19. Cyclosporine improves psoriasis in a double-blind study. Ellis, C.N., Gorsulowsky, D.C., Hamilton, T.A., Billings, J.K., Brown, M.D., Headington, J.T., Cooper, K.D., Baadsgaard, O., Duell, E.A., Annesley, T.M. JAMA (1986) [Pubmed]
  20. Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain. Forrest, W.H. JAMA (1980) [Pubmed]
  21. Effects of albuterol (salbutamol) on esophageal motility and gastroesophageal reflux in healthy volunteers. Schindlbeck, N.E., Heinrich, C., Huber, R.M., Müller-Lissner, S.A. JAMA (1988) [Pubmed]
  22. Ultrastructural appraisal of the multidrug resistance in K562 and LR73 cell lines from Fourier transform infrared spectroscopy. Le Gal, J.M., Morjani, H., Manfait, M. Cancer Res. (1993) [Pubmed]
  23. Clinical trials of gene therapy for atherosclerotic cardiovascular disease. Freedman, S.B. Curr. Opin. Lipidol. (2002) [Pubmed]
  24. Effort blood pressure control in the course of antihypertensive treatment. de Divitiis, O., Di Somma, S., Liguori, V., Petitto, M., Magnotta, C., Ausiello, M., Natale, N., Brignoli, M., Galderisi, M. Am. J. Med. (1989) [Pubmed]
  25. Reduced loss of hand bone density with prednisolone in early rheumatoid arthritis: results from a randomized placebo-controlled trial. Haugeberg, G., Strand, A., Kvien, T.K., Kirwan, J.R. Arch. Intern. Med. (2005) [Pubmed]
  26. Thyroid hormones in alcoholic liver disease. Effect of treatment with 6-n-propylthiouracil. Israel, Y., Walfish, P.G., Orrego, H., Blake, J., Kalant, H. Gastroenterology (1979) [Pubmed]
  27. Oral temafloxacin compared to norfloxacin for the treatment of complicated urinary tract infections. Cox, C.E. Am. J. Med. (1991) [Pubmed]
  28. Alendronate in the prevention of bone loss after a fracture of the lower leg. van der Poest Clement, E., van Engeland, M., Adèr, H., Roos, J.C., Patka, P., Lips, P. J. Bone Miner. Res. (2002) [Pubmed]
  29. Intracellular sodium and the response to nitrendipine or atenolol in African blacks. M'Buyamba-Kabangu, J.R., Lepira, B., Lijnen, P., Tshiani, K., Fagard, R., Amery, A. Hypertension (1988) [Pubmed]
  30. Studies on the effects of polydextrose intake on physiologic functions in Chinese people. Jie, Z., Bang-Yao, L., Ming-Jie, X., Hai-Wei, L., Zu-Kang, Z., Ting-Song, W., Craig, S.A. Am. J. Clin. Nutr. (2000) [Pubmed]
  31. Rice-based oral electrolyte solutions for the management of infantile diarrhea. Pizarro, D., Posada, G., Sandi, L., Moran, J.R. N. Engl. J. Med. (1991) [Pubmed]
  32. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. Drazen, J.M., Israel, E., Boushey, H.A., Chinchilli, V.M., Fahy, J.V., Fish, J.E., Lazarus, S.C., Lemanske, R.F., Martin, R.J., Peters, S.P., Sorkness, C., Szefler, S.J. N. Engl. J. Med. (1996) [Pubmed]
  33. Prophylactic doxycycline for travelers' diarrhea. Results of a prospective double-blind study of Peace Corps volunteers in Kenya. Sack, D.A., Kaminsky, D.C., Sack, R.B., Itotia, J.N., Arthur, R.R., Kapikian, A.Z., Orskov, F., Orskov, I. N. Engl. J. Med. (1978) [Pubmed]
  34. A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. Temkin, N.R., Dikmen, S.S., Wilensky, A.J., Keihm, J., Chabal, S., Winn, H.R. N. Engl. J. Med. (1990) [Pubmed]
  35. Effect of nicotine chewing gum in combination with group counseling on the cessation of smoking. Tønnesen, P., Fryd, V., Hansen, M., Helsted, J., Gunnersen, A.B., Forchammer, H., Stockner, M. N. Engl. J. Med. (1988) [Pubmed]
  36. Systemic ETA receptor antagonism with BQ-123 blocks ET-1 induced forearm vasoconstriction and decreases peripheral vascular resistance in healthy men. Spratt, J.C., Goddard, J., Patel, N., Strachan, F.E., Rankin, A.J., Webb, D.J. Br. J. Pharmacol. (2001) [Pubmed]
  37. The COX-2 selective inhibitor, valdecoxib, does not impair platelet function in the elderly: results of a randomized controlled trial. Leese, P.T., Recker, D.P., Kent, J.D. Journal of clinical pharmacology. (2003) [Pubmed]
  38. Atrial natriuretic hormone inhibits corticotropin-releasing hormone-induced prolactin release in man. Wiedemann, K., Herzog, L., Kellner, M. Journal of psychiatric research. (1995) [Pubmed]
  39. Simultaneous MAO-B and COMT inhibition in L-Dopa-treated patients with Parkinson's disease. Lyytinen, J., Kaakkola, S., Ahtila, S., Tuomainen, P., Teräväinen, H. Mov. Disord. (1997) [Pubmed]
  40. Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on gastric motility in duodenal ulcer patients. Konturek, J.W., Stoll, R., Menzel, J., Konturek, M., Konturek, S.J., Domschke, W. Scand. J. Gastroenterol. (2001) [Pubmed]
  41. Diflunisal. A new oral analgesic with an unusually long duration of action. Forbes, J.A., Beaver, W.T., White, E.H., White, R.W., Neilson, G.B., Shackleford, R.W. JAMA (1982) [Pubmed]
  42. Role of adjunct pharmacologic therapy in the era of drug-eluting stents. Douglas, J.S. Atherosclerosis. Supplements. (2005) [Pubmed]
  43. Preoperative morphine pre-empts postoperative pain. Richmond, C.E., Bromley, L.M., Woolf, C.J. Lancet (1993) [Pubmed]
  44. Topical lidocaine in preendoscopic medication. Gordon, M.J., Mayes, G.R., Meyer, G.W. Gastroenterology (1976) [Pubmed]
  45. Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thromboembolism in elective hip-replacement surgery: a randomised double-blind comparison. Lassen, M.R., Bauer, K.A., Eriksson, B.I., Turpie, A.G. Lancet (2002) [Pubmed]
WikiGenes - Universities