Tor signalling in bugs, brain and brawn.
TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors.[1]References
- Tor signalling in bugs, brain and brawn. Jacinto, E., Hall, M.N. Nat. Rev. Mol. Cell Biol. (2003) [Pubmed]
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