Gene Review:
Tor - Target of rapamycin
Drosophila melanogaster
Synonyms:
5092, CG5092, CT16317, CT24745, CT24817, ...
- Rheb promotes cell growth as a component of the insulin/TOR signalling network. Saucedo, L.J., Gao, X., Chiarelli, D.A., Li, L., Pan, D., Edgar, B.A. Nat. Cell Biol. (2003)
- Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress. Patel, P.H., Tamanoi, F. J. Cell. Sci. (2006)
- Genetic analysis of rolled, which encodes a Drosophila mitogen-activated protein kinase. Lim, Y.M., Nishizawa, K., Nishi, Y., Tsuda, L., Inoue, Y.H., Nishida, Y. Genetics (1999)
- Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Ravikumar, B., Vacher, C., Berger, Z., Davies, J.E., Luo, S., Oroz, L.G., Scaravilli, F., Easton, D.F., Duden, R., O'Kane, C.J., Rubinsztein, D.C. Nat. Genet. (2004)
- A nutrient sensor mechanism controls Drosophila growth. Colombani, J., Raisin, S., Pantalacci, S., Radimerski, T., Montagne, J., Léopold, P. Cell (2003)
- Amino acids and the humoral regulation of growth: fat bodies use slimfast. Bradley, G.L., Leevers, S.J. Cell (2003)
- Identification of TOR signaling complexes: more TORC for the cell growth engine. Abraham, R.T. Cell (2002)
- Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Yang, Q., Inoki, K., Ikenoue, T., Guan, K.L. Genes Dev. (2006)
- Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. Miron, M., Lasko, P., Sonenberg, N. Mol. Cell. Biol. (2003)
- Role and regulation of starvation-induced autophagy in the Drosophila fat body. Scott, R.C., Schuldiner, O., Neufeld, T.P. Dev. Cell (2004)
- Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Zhang, H., Stallock, J.P., Ng, J.C., Reinhard, C., Neufeld, T.P. Genes Dev. (2000)
- Tor signalling in bugs, brain and brawn. Jacinto, E., Hall, M.N. Nat. Rev. Mol. Cell Biol. (2003)
- Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Sarbassov, D.D., Ali, S.M., Kim, D.H., Guertin, D.A., Latek, R.R., Erdjument-Bromage, H., Tempst, P., Sabatini, D.M. Curr. Biol. (2004)
- PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Goberdhan, D.C., Meredith, D., Boyd, C.A., Wilson, C. Development (2005)
- mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Murakami, M., Ichisaka, T., Maeda, M., Oshiro, N., Hara, K., Edenhofer, F., Kiyama, H., Yonezawa, K., Yamanaka, S. Mol. Cell. Biol. (2004)
- 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Teleman, A.A., Chen, Y.W., Cohen, S.M. Genes Dev. (2005)
- Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity. Luong, N., Davies, C.R., Wessells, R.J., Graham, S.M., King, M.T., Veech, R., Bodmer, R., Oldham, S.M. Cell metabolism. (2006)
- Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase. Gayko, U., Cleghon, V., Copeland, T., Morrison, D.K., Perrimon, N. Proc. Natl. Acad. Sci. U.S.A. (1999)
- dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Radimerski, T., Montagne, J., Rintelen, F., Stocker, H., van der Kaay, J., Downes, C.P., Hafen, E., Thomas, G. Nat. Cell Biol. (2002)
- Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/dRaptor complex. Wu, M.Y., Cully, M., Andersen, D., Leevers, S.J. EMBO J. (2007)
- The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-alpha/Sima. Dekanty, A., Lavista-Llanos, S., Irisarri, M., Oldham, S., Wappner, P. J. Cell. Sci. (2005)
- TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth. Hennig, K.M., Colombani, J., Neufeld, T.P. J. Cell Biol. (2006)
- Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Gao, X., Zhang, Y., Arrazola, P., Hino, O., Kobayashi, T., Yeung, R.S., Ru, B., Pan, D. Nat. Cell Biol. (2002)
- The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila. Cygnar, K.D., Gao, X., Pan, D., Neufeld, T.P. Genetics (2005)