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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

ABT-773: pharmacokinetics and interactions with ranitidine and sucralfate.

We assessed the pharmacokinetics and interaction of ABT-773 in 12 volunteers receiving ABT-773 alone or concomitantly with ranitidine or sucralfate. Data for 150 mg of ABT-773 were as follows: the maximum concentration of the drug in plasma (C(max)) was 318 ng/ml, its half-life was 5.66 h, and its area under the plasma concentration-time curve from 0 h to infinity (AUC(0- infinity )) was 1,662 ng. h/ml. Coadministration of ranitidine, reduced the C(max) (-25.7%) and AUC(0- infinity ) (-15.8%) significantly. Sucralfate had no impact on the bioavailability of ABT-773.[1]


  1. ABT-773: pharmacokinetics and interactions with ranitidine and sucralfate. Pletz, M.W., Preechachatchaval, V., Bulitta, J., Allewelt, M., Burkhardt, O., Lode, H. Antimicrob. Agents Chemother. (2003) [Pubmed]
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