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Chemical Compound Review

Zinetac     N-[2-[[5- (dimethylaminomethyl)-2...

Synonyms: SureCN825, CHEMBL1790041, KBioGR_001475, KBioSS_001621, NINDS_000440, ...
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Disease relevance of ranitidine


Psychiatry related information on ranitidine

  • Presently, there are rare reports of gynecomastia, bradycardia, inhibition of acetylcholinesterase, headache, lethargy, diarrhea, and rash in patients receiving ranitidine [5].
  • The more convenient dosage schedule of ranitidine may be important for patient compliance with initial therapy of peptic ulcer disease, and the greater duration of ranitidine antisecretory effects may enhance effectiveness of long-term maintenance therapy by providing more complete inhibition of nocturnal acid secretion [6].
  • No change in choice reaction time or sedation index was detected after cimetidine or ranitidine dosing [7].
  • A series of N-aryl-2-[[[5-[(dimethylamino)methyl]-2- furanyl]methyl]thio]ethylamino analogs of the H2-antagonist, ranitidine, was synthesized and the abilities of the compounds to alleviate the cholinergic deficit characteristic of Alzheimer's disease evaluated [8].
  • The authors report increased serum clozapine levels and adverse side effects during clozapine and cimetidine treatment but not during clozapine and ranitidine treatment in a patient with chronic paranoid schizophrenia [9].

High impact information on ranitidine


Chemical compound and disease context of ranitidine


Biological context of ranitidine


Anatomical context of ranitidine


Associations of ranitidine with other chemical compounds


Gene context of ranitidine


Analytical, diagnostic and therapeutic context of ranitidine


  1. Ranitidine to prevent recurrence of duodenal ulcer. Merkel, P.A., Schulman, K.A. N. Engl. J. Med. (1989) [Pubmed]
  2. A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Cook, D., Guyatt, G., Marshall, J., Leasa, D., Fuller, H., Hall, R., Peters, S., Rutledge, F., Griffith, L., McLellan, A., Wood, G., Kirby, A. N. Engl. J. Med. (1998) [Pubmed]
  3. Comparison of omeprazole and ranitidine in the treatment of reflux esophagitis. Blum, A.L., Riecken, E.O., Dammann, H.G., Schiessel, R., Lux, G., Wienbeck, M., Rehner, M., Witzel, L. N. Engl. J. Med. (1986) [Pubmed]
  4. A controlled study of ranitidine for the prevention of recurrent hemorrhage from duodenal ulcer. Jensen, D.M., Cheng, S., Kovacs, T.O., Randall, G., Jensen, M.E., Reedy, T., Frankl, H., Machicado, G., Smith, J., Silpa, M. N. Engl. J. Med. (1994) [Pubmed]
  5. Problems associated with medical treatment of peptic ulcer disease. Zimmerman, T.W. Am. J. Med. (1984) [Pubmed]
  6. Review of peptic ulcer maintenance trials. Robinson, M. Am. J. Med. (1984) [Pubmed]
  7. Effect of single doses of cimetidine and ranitidine on the steady-state plasma levels of midazolam. Klotz, U., Arvela, P., Rosenkranz, B. Clin. Pharmacol. Ther. (1985) [Pubmed]
  8. Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine. Valli, M.J., Tang, Y., Kosh, J.W., Chapman, J.M., Sowell, J.W. J. Med. Chem. (1992) [Pubmed]
  9. A case report of cimetidine-induced clozapine toxicity. Szymanski, S., Lieberman, J.A., Picou, D., Masiar, S., Cooper, T. The Journal of clinical psychiatry. (1991) [Pubmed]
  10. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group. Yeomans, N.D., Tulassay, Z., Juhász, L., Rácz, I., Howard, J.M., van Rensburg, C.J., Swannell, A.J., Hawkey, C.J. N. Engl. J. Med. (1998) [Pubmed]
  11. A comparison of five maintenance therapies for reflux esophagitis. Vigneri, S., Termini, R., Leandro, G., Badalamenti, S., Pantalena, M., Savarino, V., Di Mario, F., Battaglia, G., Mela, G.S., Pilotto, A. N. Engl. J. Med. (1995) [Pubmed]
  12. Ranitidine and recurrent hemorrhage from duodenal ulcer. Loffeld, R.J., van der Putten, A.B. N. Engl. J. Med. (1994) [Pubmed]
  13. Interstitial nephritis after cimetidine but not ranitidine. Potter, P.H., Westby, R.G. JAMA (1983) [Pubmed]
  14. Famotidine, a new, potent, long-acting histamine H2-receptor antagonist: comparison with cimetidine and ranitidine in the treatment of Zollinger-Ellison syndrome. Howard, J.M., Chremos, A.N., Collen, M.J., McArthur, K.E., Cherner, J.A., Maton, P.N., Ciarleglio, C.A., Cornelius, M.J., Gardner, J.D., Jensen, R.T. Gastroenterology (1985) [Pubmed]
  15. Blocked and nonblocked acid secretion and reported pain in ulcer, nonulcer dyspepsia, and normal subjects. Bates, S., Sjödén, P.O., Fellenius, J., Nyrén, O. Gastroenterology (1989) [Pubmed]
  16. Effect of indomethacin plus ranitidine in advanced melanoma patients on high-dose interleukin-2. Mertens, W.C., Bramwell, V.H., Gwadry-Sridhar, F., Romano, W., Banerjee, D., Lala, P.K. Lancet (1992) [Pubmed]
  17. Inhibition of basal acid, chloride, and pepsin secretion in duodenal ulcer by graded doses of ranitidine and atropine with studies of pharmacokinetics of ranitidine. Hirschowitz, B.I., Danilewitz, M., Molina, E. Gastroenterology (1982) [Pubmed]
  18. Ranitidine. Strum, W.B. JAMA (1983) [Pubmed]
  19. Lack of ranitidine effects on cyclophosphamide bone marrow toxicity or metabolism: a placebo-controlled clinical trial. Alberts, D.S., Mason-Liddil, N., Plezia, P.M., Roe, D.J., Dorr, R.T., Struck, R.F., Phillips, J.G. J. Natl. Cancer Inst. (1991) [Pubmed]
  20. Furan H2-antagonist ranitidine inhibits pentagastrin-stimulated gastric secretion stronger than cimetidine. Domschke, W., Lux, G., Domschke, S. Gastroenterology (1980) [Pubmed]
  21. PACAP type I receptor activation regulates ECL cells and gastric acid secretion. Zeng, N., Athmann, C., Kang, T., Lyu, R.M., Walsh, J.H., Ohning, G.V., Sachs, G., Pisegna, J.R. J. Clin. Invest. (1999) [Pubmed]
  22. Ranitidine controls nocturnal gastric acid breakthrough on omeprazole: a controlled study in normal subjects. Peghini, P.L., Katz, P.O., Castell, D.O. Gastroenterology (1998) [Pubmed]
  23. Effects of cimetidine and ranitidine on interdigestive and postprandial lower esophageal sphincter pressures and plasma gastrin levels in normal subjects. Smout, A.J., Bogaard, J.W., van Hattum, J., Akkermans, L.M. Gastroenterology (1985) [Pubmed]
  24. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Smit, M.J., Leurs, R., Alewijnse, A.E., Blauw, J., Van Nieuw Amerongen, G.P., Van De Vrede, Y., Roovers, E., Timmerman, H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  25. The effects of cimetidine on the oxidative metabolism of estradiol. Galbraith, R.A., Michnovicz, J.J. N. Engl. J. Med. (1989) [Pubmed]
  26. A randomized trial of nonoperative treatment for perforated peptic ulcer. Crofts, T.J., Park, K.G., Steele, R.J., Chung, S.S., Li, A.K. N. Engl. J. Med. (1989) [Pubmed]
  27. Effects of ranitidine on blood alcohol levels after ethanol ingestion. Comparison with other H2-receptor antagonists. DiPadova, C., Roine, R., Frezza, M., Gentry, R.T., Baraona, E., Lieber, C.S. JAMA (1992) [Pubmed]
  28. Inhibition of pentagastrin-stimulated and nocturnal gastric secretion by ranitidine. A new H2-receptor antagonist. Peden, N.R., Saunders, J.H., Wormsley, K.G. Lancet (1979) [Pubmed]
  29. Histamine enhances interleukin (IL)-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Vannier, E., Dinarello, C.A. J. Biol. Chem. (1994) [Pubmed]
  30. Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists. Martínez, C., Albet, C., Agúndez, J.A., Herrero, E., Carrillo, J.A., Márquez, M., Benítez, J., Ortiz, J.A. Clin. Pharmacol. Ther. (1999) [Pubmed]
  31. Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FM03 gene mutations in a Korean population. Kang, J.H., Chung, W.G., Lee, K.H., Park, C.S., Kang, J.S., Shin, I.C., Roh, H.K., Dong, M.S., Baek, H.M., Cha, Y.N. Pharmacogenetics (2000) [Pubmed]
  32. Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine. Sowell, J.W., Tang, Y., Valli, M.J., Chapman, J.M., Usher, L.A., Vaughan, C.M., Kosh, J.W. J. Med. Chem. (1992) [Pubmed]
  33. Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). Bourdet, D.L., Pritchard, J.B., Thakker, D.R. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  34. Tolerance during 5 months of dosing with ranitidine, 150 mg nightly: a placebo-controlled, double-blind study. Nwokolo, C.U., Prewett, E.J., Sawyerr, A.M., Hudson, M., Lim, S., Pounder, R.E. Gastroenterology (1991) [Pubmed]
  35. Circulating pancreastatin is a marker for the enterochromaffin-like cells of the rat stomach. Håkanson, R., Ding, X.Q., Norlén, P., Chen, D. Gastroenterology (1995) [Pubmed]
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