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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Synthesis and activities of oxidative metabolites of the anti-arthritic drug candidate S-2474.

We have synthesized and characterized some oxidative metabolites of S-2474. In this study, we discovered a novel skeleton, the 2,3-dihydrobenzofuran derivative, which inhibited PGE(2) production at a very low concentration and was effective in the anti-carrageenin footpad edema assay.[1]

References

  1. Synthesis and activities of oxidative metabolites of the anti-arthritic drug candidate S-2474. Inagaki, M., Jyoyama, H., Ono, T., Yamada, K., Kobayashi, M., Baba, T., Touchi, A., Iwatani, K., Ohkawa, T., Matsumoto, S., Tsuri, T. Bioorg. Med. Chem. (2003) [Pubmed]
 
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