Can a proteomics strategy be used to identify the anti-malarial activity of chloroquine?
Interest in the mechanism of action of chloroquine is intense partly because of the emergence of drug-resistant parasites. Chloroquine resistance has been genetically linked to mutations in a parasite protein (PfCRT) that might confer resistance by inhibiting chloroquine accumulation in infected erythrocytes. Now chloroquine-binding proteins in malaria-infected erythrocytes, surprisingly, have been identified as human aldehyde dehydrogenase 1 and quinone reductase 2, raising the interesting possibility that the target of the anti-malarial activity of chloroquine might be a host enzyme.[1]References
- Can a proteomics strategy be used to identify the anti-malarial activity of chloroquine? Petri, W.A. Trends Pharmacol. Sci. (2003) [Pubmed]
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