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5838-DNI, a deoxyribonuclease inhibitor produced by Streptomyces sp. strain no. A-5838.

5838-DNI, an inhibitor of deoxyribonuclease (DNase) II from porcine spleen was produced by Streptomyces sp. strain No. A-5838. The structure of 5838-DNI was shown to be 1,4,4a,5,12,12a-hexahydro-4,4a,11,12a-tetrahydroxy-3,8-dimethoxy-9- methoxycarbonyl-10-methyl-1,5,12-trioxo naphthacene. Although similar in structure to tetracenomycin C, which is an antibiotic against Gram-positive bacteria, 5838-DNI has different antibacterial activity. 5838-DNI was distinguished from 5923-DNI, a previously reported DNase II inhibitor, in inhibitory activity against each enzyme. 5838-DNI showed dependency of inhibition on pH and temperature, and inhibited phosphodiesterase I in a competitive manner. These data suggest that 5838-DNI is the first reported example of an inhibitor of microbial origin which is able to inhibit DNase II and phosphodiesterase I.[1]

References

  1. 5838-DNI, a deoxyribonuclease inhibitor produced by Streptomyces sp. strain no. A-5838. Uyeda, M., Nagao, K., Kido, Y., Suzuki, K., Hara, Y., Yamamura, R. J. Enzym. Inhib. (1992) [Pubmed]
 
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