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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of berberine on enterotoxin-induced intestinal fluid accumulation in rats.

We have determined the effects of berberine (Berberis aristita) on intestinal fluid accumulation due to enterotoxigenic E. coli (ETEC) heat-stable ( ST) toxin in suckling (24-days old) Wistar rats. Intestinal fluid accumulation occurred in suckling Wistar rats by administration of culture filtrate containing ST-producing ETEC in serial dilutions up to 1/8 dilution by oral or intragastric route. When berberine (0.1 mg) and 1/8 dilution of ST-toxin were given together by oral or intragastric injection, a significant (p < 0.01) reduction in fluid accumulation was observed. Neither treatment with berberine orally before intragastric injection of ST-toxin nor intragastric administration of berberine after ST-toxin reduced the fluid accumulation due to ST-toxin.[1]

References

  1. Effect of berberine on enterotoxin-induced intestinal fluid accumulation in rats. Khin-Maung-U, n.u.l.l., Nwe-Nwe-Wai, n.u.l.l. Journal of diarrhoeal diseases research. (1992) [Pubmed]
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