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Rats, Wistar

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  • The effect of vanadate on blood glucose and cardiac performance was assessed in female Wistar rats 6 weeks after they were made diabetic with streptozotocin [11].
  • In male Wistar rats subjected to dietary restriction by alternate days of feeding and fasting the normal age-associated loss of striatal dopamine receptors in the brain was substantially retarded [12].
  • Male Wistar rats were anesthetized with Nembutal and were intravenously injected with 1 mg/kg of F(ab')2 or Fab fraction of either monoclonal antibody 5I2, which inhibits the function of rat counterpart of mouse Crry/p65, or monoclonal antibody 6D1, which inhibits the rat counterpart of CD59 [13].
  • Mannitol infusion in anesthetized Wistar rats resulted in an increase in urine volume, GFR, and microalbuminuria, and was also accompanied by a marked reduction in editing [14].
  • Experiments were performed in Wistar rats after 1 week of streptozotocin diabetes [15].

Chemical compound and disease context of Rats, Wistar


Biological context of Rats, Wistar


Anatomical context of Rats, Wistar


Associations of Rats, Wistar with chemical compounds


Gene context of Rats, Wistar


Analytical, diagnostic and therapeutic context of Rats, Wistar


  1. Production of adenocarcinomas of the small intestines of Wistar rats fed panfuran-S containing 3-di(hydroxymethyl)amino-6-(5-nitro-2-furylethenyl)-1,2,4-triazine. Konishi, Y., Denda, A., Takahashi, S., Inui, S., Aoki, Y. J. Natl. Cancer Inst. (1978) [Pubmed]
  2. Mucin histochemistry by paradoxical concanavalin A staining in experimental gastric cancers induced in Wistar rats by N-methyl-N-nitro-N-nitrosoguanidine or 4-nitroquinoline 1-oxide. Tatematsu, M., Katsuyama, T., Fukushima, S., Takahashi, M., Shirai, T., Ito, N., Nasu, T. J. Natl. Cancer Inst. (1980) [Pubmed]
  3. The role of transglutaminase in the rat subtotal nephrectomy model of renal fibrosis. Johnson, T.S., Griffin, M., Thomas, G.L., Skill, J., Cox, A., Yang, B., Nicholas, B., Birckbichler, P.J., Muchaneta-Kubara, C., Meguid El Nahas, A. J. Clin. Invest. (1997) [Pubmed]
  4. Possible site of zinc control of hepatoma cell division in Wistar rats. Baker, G.W., Duncan, J.R. J. Natl. Cancer Inst. (1983) [Pubmed]
  5. Enhancement of esophageal carcinogenesis induced in rats by N-amyl-N-methylnitrosamine in the presence of 12-O-tetradecanoylphorbol-13-acetate. Matsufuji, H., Ueo, H., Mori, M., Kuwano, H., Sugimachi, K. J. Natl. Cancer Inst. (1987) [Pubmed]
  6. Sodium lactate elicits a rapid increase in blood pressure in Wistar rats and spontaneously hypertensive rats. Effect of pretreatment with the antipanic drugs clomipramine and alprazolam. Wikander, I., Roos, T., Stakkestad, A., Eriksson, E. Neuropsychopharmacology (1995) [Pubmed]
  7. Hyperactivity and disruption of prepulse inhibition induced by N-methyl-D-aspartate stimulation of the ventral hippocampus and the effects of pretreatment with haloperidol and clozapine. Bast, T., Zhang, W.N., Heidbreder, C., Feldon, J. Neuroscience (2001) [Pubmed]
  8. Behavioural correlates of striatal glial fibrillary acidic protein in the 3-nitropropionic acid rat model: disturbed walking pattern and spatial orientation. Teunissen, C.E., Steinbusch, H.W., Angevaren, M., Appels, M., de Bruijn, C., Prickaerts, J., de Vente, J. Neuroscience (2001) [Pubmed]
  9. Experimental study of the effect of a series of phosphoroorganic pesticides (Dipterex and Imidan) on embryogenesis. Martson, L.V., Voronina, V.M. Environ. Health Perspect. (1976) [Pubmed]
  10. Ameliorative effects of histamine on 7-chlorokynurenic acid-induced spatial memory deficits in rats. Nishiga, M., Kamei, C. Psychopharmacology (Berl.) (2003) [Pubmed]
  11. Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats. Heyliger, C.E., Tahiliani, A.G., McNeill, J.H. Science (1985) [Pubmed]
  12. Dietary restriction retards the age-associated loss of rat striatal dopaminergic receptors. Levin, P., Janda, J.K., Joseph, J.A., Ingram, D.K., Roth, G.S. Science (1981) [Pubmed]
  13. In vivo effects of monoclonal antibodies that functionally inhibit complement regulatory proteins in rats. Matsuo, S., Ichida, S., Takizawa, H., Okada, N., Baranyi, L., Iguchi, A., Morgan, B.P., Okada, H. J. Exp. Med. (1994) [Pubmed]
  14. Suggested mechanism for the selective excretion of glucosylated albumin. The effects of diabetes mellitus and aging on this process and the origins of diabetic microalbuminuria. Kowluru, A., Kowluru, R., Bitensky, M.W., Corwin, E.J., Solomon, S.S., Johnson, J.D. J. Exp. Med. (1987) [Pubmed]
  15. Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes. Thomson, S.C., Deng, A., Bao, D., Satriano, J., Blantz, R.C., Vallon, V. J. Clin. Invest. (2001) [Pubmed]
  16. Correlation of intrahepatic pressure with collagen in the Disse space and hepatomegaly in humans and in the rat. Orrego, H., Blendis, L.M., Crossley, I.R., Medline, A., Macdonald, A., Ritchie, S., Israel, Y. Gastroenterology (1981) [Pubmed]
  17. Selective tumor kill of cerebral glioma by photodynamic therapy using a boronated porphyrin photosensitizer. Hill, J.S., Kahl, S.B., Stylli, S.S., Nakamura, Y., Koo, M.S., Kaye, A.H. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  18. Enhancement of experimental gastric carcinogenesis induced in spontaneously hypertensive rats by N-methyl-N'-nitro-N-nitrosoguanidine. Tatsuta, M., Iishi, H., Baba, M., Taniguchi, H. Cancer Res. (1989) [Pubmed]
  19. Induction of dorsolateral prostate adenocarcinomas and other accessory sex gland lesions in male Wistar rats by a single administration of N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl after sequential treatment with cyproterone acetate and testosterone propionate. Bosland, M.C., Prinsen, M.K. Cancer Res. (1990) [Pubmed]
  20. Pyrazole effects on mutagenicity and toxicity of dimethylnitrosamine in Wistar rats. Evarts, R.P., Raab, M.M., Haliday, E., Brown, C. Cancer Res. (1983) [Pubmed]
  21. Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes. Ogawa, A., Johnson, J.H., Ohneda, M., McAllister, C.T., Inman, L., Alam, T., Unger, R.H. J. Clin. Invest. (1992) [Pubmed]
  22. In vitro and in vivo DNA damage of male and female rat liver nuclei by oncogenic and nononcogenic beta blockers. Presta, M., Mazzocchi, C., Ziliani, S., Ragnotti, G. J. Natl. Cancer Inst. (1983) [Pubmed]
  23. Effects of hepatic stimulator substance, herbal medicine, selenium/vitamin E, and ciprofloxacin on cirrhosis in the rat. Zhang, M., Song, G., Minuk, G.Y. Gastroenterology (1996) [Pubmed]
  24. Enhancement by vasoactive intestinal peptide of experimental carcinogenesis induced by azoxymethane in rat colon. Iishi, H., Tatsuta, M., Baba, M., Okuda, S., Taniguchi, H. Cancer Res. (1987) [Pubmed]
  25. Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation. Castillo, T., Koop, D.R., Kamimura, S., Triadafilopoulos, G., Tsukamoto, H. Hepatology (1992) [Pubmed]
  26. Inhibition of dimethylnitrosamine-induced strand breaks in liver DNA and liver cell necrosis by diethyldithiocarbamate. Abanobi, S.E., Popp, J.A., Chang, S.K., Harrington, G.W., Lotlikar, P.D., Hadjiolov, D., Levitt, M., Rajalakshmi, S., Sarma, D.S. J. Natl. Cancer Inst. (1977) [Pubmed]
  27. Thymus lymphocytes in rats during induction of bladder tumors and effects of thymosin fraction 5 in vitro. Wada, S., Ozaki, Y., Nishio, S., Maekawa, M., Kimura, S., Kinoshita, Y. J. Natl. Cancer Inst. (1985) [Pubmed]
  28. Stress-induced activation of neuronal activity and corticotropin-releasing factor gene expression in the paraventricular nucleus is modulated by glucocorticoids in rats. Imaki, T., Xiao-Quan, W., Shibasaki, T., Yamada, K., Harada, S., Chikada, N., Naruse, M., Demura, H. J. Clin. Invest. (1995) [Pubmed]
  29. Enhanced induction by high-cholesterol diet of remnant gastric carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine in rats. Makino, M., Kaibara, N., Koga, S. J. Natl. Cancer Inst. (1989) [Pubmed]
  30. Rat Kupffer cell-derived nitric oxide modulates induction of lymphokine-activated killer cell. Kurose, I., Miura, S., Saito, H., Tada, S., Fukumura, D., Higuchi, H., Ishii, H. Gastroenterology (1995) [Pubmed]
  31. Enhancing effect of bile and bile acid on stomach tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Kobori, O., Shimizu, T., Maeda, M., Atomi, Y., Watanabe, J., Shoji, M., Morioka, Y. J. Natl. Cancer Inst. (1984) [Pubmed]
  32. Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia. Elferink, R.P., Ottenhoff, R., Liefting, W., de Haan, J., Jansen, P.L. J. Clin. Invest. (1989) [Pubmed]
  33. Separate transport systems for biliary secretion of sulfated and unsulfated bile acids in the rat. Kuipers, F., Enserink, M., Havinga, R., van der Steen, A.B., Hardonk, M.J., Fevery, J., Vonk, R.J. J. Clin. Invest. (1988) [Pubmed]
  34. Effects of acetaldehyde on cell regeneration and differentiation of the upper gastrointestinal tract mucosa. Homann, N., Kärkkäinen, P., Koivisto, T., Nosova, T., Jokelainen, K., Salaspuro, M. J. Natl. Cancer Inst. (1997) [Pubmed]
  35. Induction of liver tumors in Wistar rats by sodium nitrite given in pellet diet. Aoyagi, M., Matsukura, N., Uchida, E., Kawachi, T., Sugimura, T., Takayama, S., Matsui, M. J. Natl. Cancer Inst. (1980) [Pubmed]
  36. Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats. Huang, L., Smit, J.W., Meijer, D.K., Vore, M. Hepatology (2000) [Pubmed]
  37. Phytoestrogen-rich diets modulate expression of Brca1 and Brca2 tumor suppressor genes in mammary glands of female Wistar rats. Vissac-Sabatier, C., Coxam, V., Déchelotte, P., Picherit, C., Horcajada, M.N., Davicco, M.J., Lebecque, P., Bignon, Y.J., Bernard-Gallon, D. Cancer Res. (2003) [Pubmed]
  38. Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin. Uehara, Y., Shimizu, H., Ohtani, K., Sato, N., Mori, M. Diabetes (1998) [Pubmed]
  39. Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases. Hernandez, R., Teruel, T., de Alvaro, C., Lorenzo, M. Diabetologia (2004) [Pubmed]
  40. Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein-kinase-dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats. Kitamura, T., Kimura, K., Makondo, K., Furuya, D.T., Suzuki, M., Yoshida, T., Saito, M. Diabetologia (2003) [Pubmed]
  41. Control of glomerular hypertension by insulin administration in diabetic rats. Scholey, J.W., Meyer, T.W. J. Clin. Invest. (1989) [Pubmed]
  42. Morphologic character of transforming renal cell cultures derived from Wistar rats given dimethylnitrosamine. Hard, G.C., Borland, R. J. Natl. Cancer Inst. (1977) [Pubmed]
  43. Antibody to platelet/endothelial cell adhesion molecule-1 reduces myocardial infarct size in a rat model of ischemia-reperfusion injury. Gumina, R.J., el Schultz, J., Yao, Z., Kenny, D., Warltier, D.C., Newman, P.J., Gross, G.J. Circulation (1996) [Pubmed]
  44. Endothelin antiserum decreases volume-stimulated and basal plasma concentration of atrial natriuretic peptide. Fyhrquist, F., Sirviö, M.L., Helin, K., Saijonmaa, O., Metsärinne, K., Paakkari, I., Järvinen, A., Tikkanen, I. Circulation (1993) [Pubmed]
  45. Calcium accumulation and enzymatic activities of subcellular fractions from aortas and ventricles of genetically hypertensive rats. Wei, J.W., Janis, R.A., Daniel, E.E. Circ. Res. (1976) [Pubmed]
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