Cell-derived sequences in the N-terminal region of the polyprotein of a cytopathogenic pestivirus.
Efficient proteolytic release of nonstructural protein 3 (NS3) from the viral polyprotein is considered to be crucial for the cytopathogenicity of pestiviruses. Here we describe a novel cytopathogenic (cp) bovine viral diarrhea virus strain (BVDV CP8) with a complex insertion composed of viral and cell-derived sequences, including two fragments of the cellular J-domain protein Jiv (J-domain protein interacting with viral protein) located in the N-terminal region of the polyprotein. BVDV CP8 expresses a Jiv fusion protein of 513 amino acids in addition to a complete set of viral proteins. This protein has the capacity to induce NS2-3 cleavage in trans. Accordingly, CP8 is a representative of a novel type of cp pestivirus with a cp-specific mutation located outside of the NS2-3 gene.[1]References
- Cell-derived sequences in the N-terminal region of the polyprotein of a cytopathogenic pestivirus. Müller, A., Rinck, G., Thiel, H.J., Tautz, N. J. Virol. (2003) [Pubmed]
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