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MeSH Review


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Disease relevance of Pestivirus


High impact information on Pestivirus


Chemical compound and disease context of Pestivirus

  • Thus, the acridone scaffold, when appropriately functionalized, can yield compounds with selective activity against pestiviruses and related viruses such as the HCV [10].
  • Extensive analyses of amino acid sequences for the viral structural proteins and nonstructural protein p54 regions from five pestiviruses led to the identification of four conserved domains (designated as C1, C2, C3, C4) and three highly variable domains (designated as V1, V2, V3) within this region [11].
  • Immunohistochemical detection of pestivirus was poor in cases of ovine abortion, ovine hairy shaker syndrome, and caprine abortion [12].
  • Two months later the flock was reconstituted and after a further three weeks, the ewes were bred to pestivirus negative rams after synchronisation of oestrus using progesterone sponges [13].
  • Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C [14].

Biological context of Pestivirus

  • Preceding the polyprotein start codon, multiple cryptic AUG codons and several small open reading frames are characteristic for all the five pestiviruses [8].
  • The pestivirus bovine viral diarrhea virus (BVDV) p80 protein (referred to here as the NS3 protein) contains amino acid sequence motifs predictive of three enzymatic activities: serine proteinase, nucleoside triphosphatase, and RNA helicase [15].
  • Ribosomal S27a coding sequences upstream of ubiquitin coding sequences in the genome of a pestivirus [16].

Gene context of Pestivirus


  1. The NS5A protein of hepatitis C virus is a zinc metalloprotein. Tellinghuisen, T.L., Marcotrigiano, J., Gorbalenya, A.E., Rice, C.M. J. Biol. Chem. (2004) [Pubmed]
  2. N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases. Gorbalenya, A.E., Donchenko, A.P., Koonin, E.V., Blinov, V.M. Nucleic Acids Res. (1989) [Pubmed]
  3. Mutations abrogating the RNase activity in glycoprotein E(rns) of the pestivirus classical swine fever virus lead to virus attenuation. Meyers, G., Saalmüller, A., Büttner, M. J. Virol. (1999) [Pubmed]
  4. Proteomics computational analyses suggest that hepatitis C virus E1 and pestivirus E2 envelope glycoproteins are truncated class II fusion proteins. Garry, R.F., Dash, S. Virology (2003) [Pubmed]
  5. The pestivirus E(rns) glycoprotein interacts with E2 in both infected cells and mature virions. Lazar, C., Zitzmann, N., Dwek, R.A., Branza-Nichita, N. Virology (2003) [Pubmed]
  6. Possible role of pestiviruses in microcephaly. Potts, B.J., Sever, J.L., Tzan, N.R., Huddleston, D., Elder, G.A. Lancet (1987) [Pubmed]
  7. Translocation activity of C-terminal domain of pestivirus Erns and ribotoxin L3 loop. Langedijk, J.P. J. Biol. Chem. (2002) [Pubmed]
  8. 5' and 3' untranslated regions of pestivirus genome: primary and secondary structure analyses. Deng, R., Brock, K.V. Nucleic Acids Res. (1993) [Pubmed]
  9. Core protein of pestiviruses is processed at the C terminus by signal peptide peptidase. Heimann, M., Sosa, G.R., Martoglio, B., Thiel, H.J., Rümenapf, T. J. Virol. (2006) [Pubmed]
  10. Synthesis and anti-BVDV activity of acridones as new potential antiviral agents. Tabarrini, O., Manfroni, G., Fravolini, A., Cecchetti, V., Sabatini, S., De Clercq, E., Rozenski, J., Canard, B., Dutartre, H., Paeshuyse, J., Neyts, J. J. Med. Chem. (2006) [Pubmed]
  11. Molecular cloning and nucleotide sequence of a pestivirus genome, noncytopathic bovine viral diarrhea virus strain SD-1. Deng, R., Brock, K.V. Virology (1992) [Pubmed]
  12. Diagnosis of naturally occurring bovine viral diarrhea virus infections in ruminants using monoclonal antibody-based immunohistochemistry. Baszler, T.V., Evermann, J.F., Kaylor, P.S., Byington, T.C., Dilbeck, P.M. Vet. Pathol. (1995) [Pubmed]
  13. Foetal cross-protection experiments between type 1 and type 2 bovine viral diarrhoea virus in pregnant ewes. Paton, D.J., Sharp, G., Ibata, G. Vet. Microbiol. (1999) [Pubmed]
  14. Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C. Whitby, K., Taylor, D., Patel, D., Ahmed, P., Tyms, A.S. Antivir. Chem. Chemother. (2004) [Pubmed]
  15. Pestivirus NS3 (p80) protein possesses RNA helicase activity. Warrener, P., Collett, M.S. J. Virol. (1995) [Pubmed]
  16. Ribosomal S27a coding sequences upstream of ubiquitin coding sequences in the genome of a pestivirus. Becher, P., Orlich, M., Thiel, H.J. J. Virol. (1998) [Pubmed]
  17. Insertion of cellular NEDD8 coding sequences in a pestivirus. Baroth, M., Orlich, M., Thiel, H.J., Becher, P. Virology (2000) [Pubmed]
  18. Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication. Xu, J., Mendez, E., Caron, P.R., Lin, C., Murcko, M.A., Collett, M.S., Rice, C.M. J. Virol. (1997) [Pubmed]
  19. Processing of a pestivirus protein by a cellular protease specific for light chain 3 of microtubule-associated proteins. Fricke, J., Voss, C., Thumm, M., Meyers, G. J. Virol. (2004) [Pubmed]
  20. Complete genomic sequence of border disease virus, a pestivirus from sheep. Becher, P., Orlich, M., Thiel, H.J. J. Virol. (1998) [Pubmed]
  21. Cell-derived sequences in the N-terminal region of the polyprotein of a cytopathogenic pestivirus. Müller, A., Rinck, G., Thiel, H.J., Tautz, N. J. Virol. (2003) [Pubmed]
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