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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The determination of the preservative, chlorocresol, in a pharmaceutical formulation by flow injection analysis.

A flow injection analysis (FIA) procedure is described for the determination of chlorocresol in a parenteral pharmaceutical formulation. The product is directly injected into a carrier stream of water and subsequently reacted with a reagent stream of nitrous acid. The resulting brown nitro-derivative is determined spectrophotometrically at 400 nm. The method has been validated and should be applicable to chlorocresol in other pharmaceutical products and to compounds containing a phenolic ring, assuming absence of matrix interference.[1]

References

  1. The determination of the preservative, chlorocresol, in a pharmaceutical formulation by flow injection analysis. Bloomfield, M.S., Prebble, K.A. Journal of pharmaceutical and biomedical analysis. (1992) [Pubmed]
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